Literature summary for 2.7.11.1 extracted from

Nakagawa, H.; Koyama, K.; Miyoshi, Y.; Ando, H.; Baba, S.; Watatani, M.; Yasutomi, M.; Matsuura, N.; Monden, M.; Nakamura, Y.
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome (1998), Hum. Genet., 103, 168-172.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	Peutz-Jeghers syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer, germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15831	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Peutz-Jeghers syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer, germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
serine/threonine-protein kinase 11	-	Homo sapiens

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Release 2023.1 (January 2023)