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Literature summary for 2.7.11.1 extracted from

  • Enerbaeck, S.
    Casein kinase 2 - a kinase that inhibits brown fat formation (2015), Cell Metab., 22, 958-959 .
    View publication on PubMed
Search for more literature for 2.7.11.1

Application

Application Comment Organism
medicine regulating CK2 activity may be useful to provide a safe and efficient way of activating brown adipose tissue in humans so that the beneficial effects of having ample amounts of brown fat can be made available to all that suffer from obesity and obesity-linked maladies such as type 2 diabetes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information CK2 is suppressed in white adipocytes by RNAi Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CX-4945 a CK2 inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte white, brown and beige adipocyte Homo sapiens
-
adipose tissue
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
casein kinase 2
-
 Homo sapiens
CK2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens after norepinephrine administration, caseine kinase 2 (CK2), is induced and more active in primary white adipocytes compared to both brown and beige adipocytes. CK2 activity is induced in the inguinal white adipose tissue depot after high-fat feeding. This increase in CK2 activity is selective for white adipose tissue since no change in CK2 activity is found in brown adipose tissue up

General Information

General Information Comment Organism
malfunction when CK2 is suppressed in white adipocytes, either by RNAi or a pharmacological approach using the CK2 inhibitor CX-4945, there occurs a robust induction of Ucp1 and several other brown selective genes such as Cidea, Cited1, and Elov3. Phosphorylation of class I HDACs, HDAC1 and HDAC2, is strikingly reduced by CK2 inhibition in white adipocytes, consistent with increased browning, since inhibition of class I HDACs is linked to increased expression of PGC1alpha Homo sapiens
physiological function casein kinase 2 (CK2) is a suppressor of brown adipocyte formation, role of CK2 as a repressor of browning in adipose tissue, overview. Expression/suppression of CK2 is involved in how adipose tissue regulates its cellular composition of brown versus white adipocytes Homo sapiens