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Literature summary for 2.7.11.1 extracted from
- Specificity of G protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell M3 muscarinic acetylcholine receptor signaling (2003), Mol. Pharmacol., 64, 1059-1068.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable 20fold overexpression of K46R mutant CK1alpha in SH-SY5Y neuroblastoma cells via adenovirus infection system | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K46R | site-directed mutagenesis, inactive, dominant negative mutants of CK1alpha, overexpression in SH-SY5Y cells does not influence endogenous basal and metacholine-stimulated M3 muscarinic acetylcholine receptor phosphorylation and desensitization by the endogenous wild-type GRK6 | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-casein | Homo sapiens | casein kinase 1alpha | ADP + phosphorylated alpha-casein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| SH-SY5Y cell | neuroblastoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-casein | casein kinase 1alpha | Homo sapiens | ADP + phosphorylated alpha-casein | - |
? | |
| ATP + [M3 muscarinic acetylcholine receptor] | recombinant substrate expressed in HEK-293 and CHO cells, casein kinase 1alpha | Homo sapiens | ADP + phospho-[M3 muscarinic acetylcholine receptor] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| casein kinase 1alpha | - |
Homo sapiens |
| CK1alpha | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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