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Literature summary for 2.7.11.1 extracted from

  • Udo, H.; Munoz-Dorado, J.; Inouye, M.; Inouye, S.
    Myxococcus xanthus, a gram-negative bacterium, contains a transmembrane protein serine/threonine kinase that blocks the secretion of beta-lactamase by phosphorylation (1995), Genes Dev., 9, 972-983.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli under a T7 promoter Myxococcus xanthus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane Pkn2 is a transmembrane protein with the kinase domain in the cytoplasm and the 207-residue carboxy-terminal domain outside the cytoplasmic membrane Myxococcus xanthus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Myxococcus xanthus the enzyme blocks the secretion of beta-lactamase by phosphorylation ADP + a phosphoprotein
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 ?

Organism

Organism UniProt Comment Textmining
Myxococcus xanthus P54736
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylated at both Ser and Thr residues Myxococcus xanthus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein the enzyme blocks the secretion of beta-lactamase by phosphorylation Myxococcus xanthus ADP + a phosphoprotein
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 ?
ATP + TEM-beta-lactamase the enzyme is phosphorylated only at Thr residues, shifting its apparent molecular mass from 29000 Da to 44000 Da. The phosphorylated beta-lactamase is unable to be secreted into the periplasmic space and localized in the cytoplasmic and membrane fractions Myxococcus xanthus ADP + phosphorylated TEM-beta-lactamase
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 ?

Synonyms

Synonyms Comment Organism
serine/threonine-protein kinase pkn2
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 Myxococcus xanthus