Protein Variants | Comment | Organism |
---|---|---|
additional information | replacement of Thr508 with 2 glutamic acid residues results in a fully active enzyme | Homo sapiens |
T508V | activity is abolished | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein | Homo sapiens | phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes | ADP + protein tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P53667 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation is an essential regulatory feature of LIM kinase, threonine 508 and the adjacent basic insert sequences of the activation loop are required for this process | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein | phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes | Homo sapiens | ADP + protein tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LIM domain kinase 1 | - |
Homo sapiens |