Any feedback?
Literature summary for 2.7.11.1 extracted from
- Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication (2010), Mol. Cell. Biol., 30, 131-145.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histine H2A | Saccharomyces cerevisiae | phosphorylation on serine 129 in vivo | ADP + histidine gammaH2A | Glc7 dephosphorylates histidine gammaH2A in vitro | ? |  |
| additional information | Saccharomyces cerevisiae | Glc7 promotes resumption of DNA replication by inactivating Rad53 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histine H2A | phosphorylation on serine 129 in vivo | Saccharomyces cerevisiae | ADP + histidine gammaH2A | Glc7 dephosphorylates histidine gammaH2A in vitro | ? | |
| additional information | Glc7 promotes resumption of DNA replication by inactivating Rad53 | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Glc7 | catalytic subunit of protein phosphatase 1 | Saccharomyces cerevisiae |
| PP1 | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Glc7 is required for recovery from a double-strand break-induced checkpoint, while it is dispensable for checkpoint inactivation during methylmethane sulfonate exposure, Glc7 is not required for homologous recombination-mediated double-strand break repair | Saccharomyces cerevisiae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
