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Literature summary for 2.7.11.1 extracted from

  • Guerra, B.
    Protein kinase CK2 subunits are positive regulators of AKT kinase (2006), Int. J. Oncol., 28, 685-693.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of subunits CK2alpha and CK2beta, and of the CK2 holoenzyme in Escherichia coli, expression of Myc-tagged CK2beta in GV10.15 cells, expression of the human Drosophila homologue CK2ยท-Timekeeper Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information HeLa cells are depleted of CK2 subunits by treatment with CK2 antisense oligodeoxynucleotides directed against the catalytic alpha/alpha' and regulatory beta subunits prior induction of apoptosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RRRDDDSDDD a CK2-specific synthetic peptide substrate Homo sapiens ADP + RRRDDDphosphoSDDD
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?
additional information CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview Homo sapiens ?
-
?
additional information protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
protein kinase CK2
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
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Homo sapiens