Literature summary for 2.7.11.1 extracted from

Pallova, P.; Hercik, K.; Saskova, L.; Novakova, L.; Branny, P.
A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivo (2007), Biochem. Biophys. Res. Commun., 355, 526-530.

Search for more literature for 2.7.11.1

Cloned(Commentary)

Cloned (Comment)	Organism
expression of full-length and truncated StkP forms in Escherichia coli, overview	Streptococcus pneumoniae

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of the extracellular domain of StkP negatively affects the stability of a core kinase domain	Streptococcus pneumoniae

General Stability

General Stability	Organism
the extracellular domain of StkP is required for the stability of a core kinase domain, while the membrane-anchored kinase domain and the full-length form of StkP are stable and capable of autophosphorylation	Streptococcus pneumoniae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	membrane anchored kinase domain	Streptococcus pneumoniae	16020	-
additional information	subcellular localization of different epitope labeled forms of StkP, overview	Streptococcus pneumoniae	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Streptococcus pneumoniae

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
202000	-	recombinant phosphorylated, full-length enzyme, native PAGE	Streptococcus pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae	-	gene stkP	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	StkP performs autophosphorylation	Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	StkP performs autophosphorylation	Streptococcus pneumoniae	?	-	?

Subunits

Subunits	Comment	Organism
dimer	homodimerization in vivo, recombinant enzyme	Streptococcus pneumoniae

Synonyms

Synonyms	Comment	Organism
eukaryotic-type serine/threonine protein kinase	-	Streptococcus pneumoniae
Ser/Thr protein kinase	-	Streptococcus pneumoniae
StkP	-	Streptococcus pneumoniae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Streptococcus pneumoniae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Streptococcus pneumoniae

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Streptococcus pneumoniae

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Release 2023.1 (January 2023)