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Literature summary for 2.7.11.1 extracted from

  • Lu, S.; Liu, H.; Knowles, S.; Li, J.; Ma, L.; Tobin, E.; Lin, C.
    A role for protein kinase casein kinase2 alpha-subunits in the Arabidopsis circadian clock (2011), Plant Physiol., 157, 1537-1545.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Protein Variants

Protein Variants Comment Organism
additional information generation of a cka1a2a3 triple mutant, with loss-of-function mutations in three nuclear-localized CK2alpha subunits affecting the pace of the circadian clock Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
 Arabidopsis thaliana
heparin a specific inhibitor of CK2 Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + CIRCADIAN CLOCK ASSOCIATED1 Arabidopsis thaliana transcription factor CIRCADIAN CLOCK ASSOCIATED1, i.e. CCA1 ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
-
 ?
ATP + CIRCADIAN CLOCK ASSOCIATED1 Arabidopsis thaliana Col-0 transcription factor CIRCADIAN CLOCK ASSOCIATED1, i.e. CCA1 ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 genes cka1, cka2, cka3, and cka4 encoding the four subunits
-
Arabidopsis thaliana Col-0
-
 genes cka1, cka2, cka3, and cka4 encoding the four subunits
-

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CIRCADIAN CLOCK ASSOCIATED1
-
 Arabidopsis thaliana ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
-
 ?
ATP + CIRCADIAN CLOCK ASSOCIATED1 transcription factor CIRCADIAN CLOCK ASSOCIATED1, i.e. CCA1 Arabidopsis thaliana ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
-
 ?
ATP + CIRCADIAN CLOCK ASSOCIATED1
-
 Arabidopsis thaliana Col-0 ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
-
 ?
ATP + CIRCADIAN CLOCK ASSOCIATED1 transcription factor CIRCADIAN CLOCK ASSOCIATED1, i.e. CCA1 Arabidopsis thaliana Col-0 ADP + phosphorylated CIRCADIAN CLOCK ASSOCIATED1
-
 ?

Subunits

Subunits Comment Organism
tetramer alpha2beta2, the enzyme is composed of two catalytic alpha-subunits and two regulatory beta-subunits Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
casein kinase2
-
 Arabidopsis thaliana
CK2
-
 Arabidopsis thaliana
Ser/Thr protein kinase
-
 Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution casein kinase2 is an evolutionarily conserved serine/threonine protein kinase composed of two catalytic alpha-subunits and two regulatory beta-subunits. Although most of the molecular components responsible for circadian function are not conserved between kingdoms, CK2 is a well-conserved clock component modulating the stability and subcellular localization of essential clock proteins Arabidopsis thaliana
malfunction the overall activity of the CK2 holoenzyme is affected by the cka1a2a3 triple mutations, and phosphorylation of CCA1 is reduced in the triple mutant. The photoperiodic flowering response, which is regulated by circadian rhythms, is reduced in the cka1a2a3 triple mutant and the plants flower later under long-day conditions Arabidopsis thaliana
physiological function phosphorylation of clock proteins by the enzyme plays a critical role in generating proper circadian rhythms. CK2alpha subunits are important components of the Arabidopsis circadian system and their effects on rhythms are in part due to their phosphorylation of CIRCADIAN CLOCK ASSOCIATED1 Arabidopsis thaliana