Reference on EC 3.4.21.122 - transmembrane protease serine 2
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yamamoto, M.; Matsuyama, S.; Li, X.; Takeda, M.; Kawaguchi, Y.; Inoue, J.I.; Matsuda, Z.
Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome coronavirus S protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay
Antimicrob. Agents Chemother.
60
6532-6539
2016
Homo sapiens (O15393)
Wilson, S.; Greer, B.; Hooper, J.; Zijlstra, A.; Walker, B.; Quigley, J.; Hawthorne, S.
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells
Biochem. J.
388
967-972
2005
Homo sapiens (O15393)
Meyer, D.; Sielaff, F.; Hammami, M.; Boettcher-Friebertshaeuser, E.; Garten, W.; Steinmetzer, T.
Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation
Biochem. J.
452
331-343
2013
Homo sapiens (O15393)
Wen, Z.; Wu, C.; Chen, W.; Zeng, X.; Shi, J.; Ge, J.; Chen, H.; Bu, Z.
Establishment of MDCK stable cell lines expressing TMPRSS2 and MSPL and their applications in propagating influenza vaccine viruses in absence of exogenous trypsin
Biotechnol. Res. Int.
2015
402628
2015
Homo sapiens
Lucas, J.M.; Heinlein, C.; Kim, T.; Hernandez, S.A.; Malik, M.S.; True, L.D.; Morrissey, C.; Corey, E.; Montgomery, B.; Mostaghel, E.; Clegg, N.; Coleman, I.; Brown, C.M.; Schneider, E.L.; Craik, C.; Simon, J.A.; Bedalov, A.; Nelson, P.S.
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis
Cancer Discov.
4
1310-1325
2014
Homo sapiens (O15393), Mus musculus (Q9JIQ8)
Ko, C.J.; Huang, C.C.; Lin, H.Y.; Juan, C.P.; Lan, S.W.; Shyu, H.Y.; Wu, S.R.; Hsiao, P.W.; Huang, H.P.; Shun, C.T.; Lee, M.S.
Androgen-induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasis
Cancer Res.
75
2949-2960
2015
Homo sapiens (O15393)
Chen, Z.; Song, X.; Li, Q.; Xie, L.; Guo, T.; Su, T.; Tang, C.; Chang, X.; Liang, B.; Huang, D.
Androgen receptor-activated enhancers simultaneously regulate oncogene TMPRSS2 and lncRNA PRCAT38 in prostate cancer
Cells
8
864
2019
Homo sapiens (O15393)
Hayashi, H.; Kubo, Y.; Izumida, M.; Takahashi, E.; Kido, H.; Sato, K.; Yamaya, M.; Nishimura, H.; Nakayama, K.; Matsuyama, T.
Enterokinase enhances influenza A virus infection by activating trypsinogen in human cell lines
Front. Cell. Infect. Microbiol.
8
91
2018
Homo sapiens (O15393)
Ubuka, T.; Moriya, S.; Soga, T.; Parhar, I.
Identification of transmembrane protease serine 2 and forkhead box A1 as the potential bisphenol A responsive genes in the neonatal male rat brain
Front. Endocrinol. (Lausanne)
9
139
2018
Rattus norvegicus (Q6P7D7), Rattus norvegicus
Wang, S.; Zhang, Q.; Xu, D.; Pan, Y.; Lv, Y.; Chen, X.; Zuo, Y.; Yang, L.
Characterize the difference between TMPRSS2-ERG and non-TMPRSS2-ERG fusion patients by clinical and biological characteristics in prostate cancer
Gene
679
186-194
2018
Homo sapiens
Sabaliauskaite, R.; Jarmalaite, S.; Petroska, D.; Dasevicius, D.; Laurinavicius, A.; Jankevicius, F.; Lazutka, J.R.
Combined analysis of TMPRSS2-ERG and TERT for improved prognosis of biochemical recurrence in prostate cancer
Genes Chromosomes Cancer
51
781-791
2012
Homo sapiens (O15393)
Paoloni-Giacobino, A.; Chen, H.; Peitsch, M.C.; Rossier, C.; Antonarakis, S.E.
Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3
Genomics
44
309-320
1997
Homo sapiens (O15393)
Esumi, M.; Ishibashi, M.; Yamaguchi, H.; Nakajima, S.; Tai, Y.; Kikuta, S.; Sugitani, M.; Takayama, T.; Tahara, M.; Takeda, M.; Wakita, T.
Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection
Hepatology
61
437-446
2015
Homo sapiens (O15393), Homo sapiens
Paszti-Gere, E.; Barna, R.F.; Kovago, C.; Szauder, I.; Ujhelyi, G.; Jakab, C.; Meggyeshzi, N.; Szekacs, A.
Changes in the distribution of type II transmembrane serine protease, TMPRSS2 and in paracellular permeability in IPEC-J2 cells exposed to oxidative stress
Inflammation
38
775-783
2015
Sus scrofa
Ferrara, F.; Molesti, E.; Boettcher-Friebertshaeuser, E.; Cattoli, G.; Corti, D.; Scott, S.D.; Temperton, N.J.
The human transmembrane protease serine 2 is necessary for the production of group 2 influenza A virus pseudotypes
J. Mol. Genet. Med.
7
309-314
2012
Homo sapiens (O15393), Homo sapiens
Vaarala, M.H.; Porvari, K.S.; Kellokumpu, S.; Kyllnen, A.P.; Vihko, P.T.
Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues
J. Pathol.
193
134-140
2001
Homo sapiens (O15393), Mus musculus (Q9JIQ8)
Boettcher, E.; Matrosovich, T.; Beyerle, M.; Klenk, H.D.; Garten, W.; Matrosovich, M.
Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium
J. Virol.
80
9896-9898
2006
Homo sapiens (O15393)
Matsuyama, S.; Nagata, N.; Shirato, K.; Kawase, M.; Takeda, M.; Taguchi, F.
Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2
J. Virol.
84
12658-12664
2010
Homo sapiens (O15393)
Boettcher-Friebertshaeuser, E.; Freuer, C.; Sielaff, F.; Schmidt, S.; Eickmann, M.; Uhlendorff, J.; Steinmetzer, T.; Klenk, H.D.; Garten, W.
Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors
J. Virol.
84
5605-5614
2010
Homo sapiens (O15393)
Bertram, S.; Glowacka, I.; Mueller, M.A.; Lavender, H.; Gnirss, K.; Nehlmeier, I.; Niemeyer, D.; He, Y.; Simmons, G.; Drosten, C.; Soilleux, E.J.; Jahn, O.; Steffen, I.; Poehlmann, S.
Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease
J. Virol.
85
13363-13372
2011
Homo sapiens (O15393), Homo sapiens
Boettcher-Friebertshaeuser, E.; Stein, D.A.; Klenk, H.D.; Garten, W.
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2
J. Virol.
85
1554-1562
2011
Homo sapiens (O15393)
Glowacka, I.; Bertram, S.; Mueller, M.A.; Allen, P.; Soilleux, E.; Pfefferle, S.; Steffen, I.; Tsegaye, T.S.; He, Y.; Gnirss, K.; Niemeyer, D.; Schneider, H.; Drosten, C.; Poehlmann, S.
Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response
J. Virol.
85
4122-4134
2011
Homo sapiens (O15393)
Shulla, A.; Heald-Sargent, T.; Subramanya, G.; Zhao, J.; Perlman, S.; Gallagher, T.
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry
J. Virol.
85
873-882
2011
Homo sapiens (O15393), Homo sapiens
Abe, M.; Tahara, M.; Sakai, K.; Yamaguchi, H.; Kanou, K.; Shirato, K.; Kawase, M.; Noda, M.; Kimura, H.; Matsuyama, S.; Fukuhara, H.; Mizuta, K.; Maenaka, K.; Ami, Y.; Esumi, M.; Kato, A.; Takeda, M.
TMPRSS2 is an activating protease for respiratory parainfluenza viruses
J. Virol.
87
11930-11935
2013
Homo sapiens (O15393)
Shirato, K.; Kawase, M.; Matsuyama, S.
Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2
J. Virol.
87
12552-12561
2013
Homo sapiens (O15393)
Baron, J.; Tarnow, C.; Mayoli-Nuessle, D.; Schilling, E.; Meyer, D.; Hammami, M.; Schwalm, F.; Steinmetzer, T.; Guan, Y.; Garten, W.; Klenk, H.D.; Boettcher-Friebertshaeuser, E.
Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses
J. Virol.
87
1811-1820
2013
Homo sapiens (O15393)
Gierer, S.; Bertram, S.; Kaup, F.; Wrensch, F.; Heurich, A.; Kraemer-Kuehl, A.; Welsch, K.; Winkler, M.; Meyer, B.; Drosten, C.; Dittmer, U.; von Hahn, T.; Simmons, G.; Hofmann, H.; Poehlmann, S.
The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies
J. Virol.
87
5502-5511
2013
Homo sapiens (O15393)
Bertram, S.; Dijkman, R.; Habjan, M.; Heurich, A.; Gierer, S.; Glowacka, I.; Welsch, K.; Winkler, M.; Schneider, H.; Hofmann-Winkler, H.; Thiel, V.; Poehlmann, S.
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium
J. Virol.
87
6150-6160
2013
Homo sapiens (O15393)
Heurich, A.; Hofmann-Winkler, H.; Gierer, S.; Liepold, T.; Jahn, O.; Poehlmann, S.
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein
J. Virol.
88
1293-1307
2014
Homo sapiens (O15393)
Kuehn, N.; Bergmann, S.; Koesterke, N.; Lambertz, R.L.O.; Keppner, A.; van den Brand, J.M.A.; Poehlmann, S.; Weiss, S.; Hummler, E.; Hatesuer, B.; Schughart, K.
The proteolytic activation of (H3N2) influenza A virus hemagglutinin is facilitated by different type II transmembrane serine proteases
J. Virol.
90
4298-4307
2016
Mus musculus (Q9JIQ8)
Shirato, K.; Kanou, K.; Kawase, M.; Matsuyama, S.
Clinical isolates of human coronavirus 229E bypass the endosome for cell entry
J. Virol.
91
e01387
2016
Homo sapiens (O15393), Homo sapiens
Phillips, J.M.; Gallagher, T.; Weiss, S.R.
Neurovirulent murine coronavirus JHM.SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion
J. Virol.
91
e01564
2017
Homo sapiens (O15393)
Limburg, H.; Harbig, A.; Bestle, D.; Stein, D.A.; Moulton, H.M.; Jaeger, J.; Janga, H.; Hardes, K.; Koepke, J.; Schulte, L.; Koczulla, A.R.; Schmeck, B.; Klenk, H.D.; Boettcher-Friebertshaeuser, E.
TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes
J. Virol.
93
e00649
2019
Homo sapiens (O15393)
Iwata-Yoshikawa, N.; Okamura, T.; Shimizu, Y.; Hasegawa, H.; Takeda, M.; Nagata, N.
TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection
J. Virol.
93
e01815
2019
Mus musculus (Q9JIQ8)
Kim, T.S.; Heinlein, C.; Hackman, R.C.; Nelson, P.S.
Phenotypic analysis of mice lacking the Tmprss2-encoded protease
Mol. Cell. Biol.
26
965-975
2006
Mus musculus (Q9JIQ8)
Sun, C.; Dobi, A.; Mohamed, A.; Li, H.; Thangapazham, R.L.; Furusato, B.; Shaheduzzaman, S.; Tan, S.H.; Vaidyanathan, G.; Whitman, E.; Hawksworth, D.J.; Chen, Y.; Nau, M.; Patel, V.; Vahey, M.; Gutkind, J.S.; Sreenath, T.; Petrovics, G.; Sesterhenn, I.A.; McLeod, D.G.; Srivastava, S.
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation
Oncogene
27
5348-5353
2008
Homo sapiens (O15393)
Zmora, P.; Moldenhauer, A.S.; Hofmann-Winkler, H.; Poehlmann, S.
TMPRSS2 isoform 1 activates respiratory viruses and is expressed in viral target cells
PLoS ONE
10
e0138380
2015
Homo sapiens (O15393)
Reinke, L.M.; Spiegel, M.; Plegge, T.; Hartleib, A.; Nehlmeier, I.; Gierer, S.; Hoffmann, M.; Hofmann-Winkler, H.; Winkler, M.; Poehlmann, S.
Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2
PLoS ONE
12
e0179177
2017
Homo sapiens (O15393)
Bertram, S.; Heurich, A.; Lavender, H.; Gierer, S.; Danisch, S.; Perin, P.; Lucas, J.M.; Nelson, P.S.; Poehlmann, S.; Soilleux, E.J.
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts
PLoS ONE
7
e35876
2012
Sus scrofa, Homo sapiens (O15393), Mus musculus (Q9JIQ8)
Kleine-Weber, H.; Elzayat, M.T.; Hoffmann, M.; Poehlmann, S.
Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein
Sci. Rep.
8
16597
2018
Homo sapiens (O15393)
Boettcher, E.; Freuer, C.; Steinmetzer, T.; Klenk, H.D.; Garten, W.
MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition
Vaccine
27
6324-6329
2009
Homo sapiens (O15393)
Shirato, K.; Kawase, M.; Matsuyama, S
Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry
Virology
517
9-15
2018
Homo sapiens (O15393), Homo sapiens
Mettelman, R.C.; OBrien, A.; Whittaker, G.R.; Baker, S.C.
Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus
Virology
537
226-236
2019
Felis catus (M3W8X2)
Bilinska, K.; Jakubowska, P.; Von Bartheld, C.S.; Butowt, R.
Expression of the SARS-CoV-2 entry proteins, ACE2 and TMPRSS2, in cells of the olfactory epithelium identification of cell types and trends with age
ACS Chem. Neurosci.
11
1555-1562
2020
Mus musculus
Kawasumi, T.; Takeno, S.; Ishino, T.; Ueda, T.; Hamamoto, T.; Takemoto, K.; Horibe, Y.; Takashi, O.
Co-expression and localization of angiotensin-converting enzyme-2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) in paranasal ciliated epithelium of patients with chronic rhinosinusitis
Am. J. Rhinol. Allergy
36
313-322
2022
Homo sapiens (O15393)
Afar, D.E.; Vivanco, I.; Hubert, R.S.; Kuo, J.; Chen, E.; Saffran, D.C.; Raitano, A.B.; Jakobovits, A.
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia
Cancer Res.
61
1686-1692
2001
Homo sapiens (O15393)
Yu, Y.; Herrmann, A.; Thonn, V.; Cordsmeier, A.; Neurath, M.; Ensser, A.; Becker, C.
SMYD2 inhibition downregulates TMPRSS2 and decreases SARS-CoV-2 infection in human intestinal and airway epithelial cells
Cells
11
1262
2022
Homo sapiens (O15393)
Rajput, S.K.; Logsdon, D.M.; Kile, B.; Engelhorn, H.J.; Goheen, B.; Khan, S.; Swain, J.; McCormick, S.; Schoolcraft, W.B.; Yuan, Y.; Krisher, R.L.
Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection
F S Sci.
2
33-42
2021
Homo sapiens (C9JKZ3), Homo sapiens
Jacquinet, E.; Rao, N.V.; Rao, G.V.; Hoidal, J.R.
Cloning, genomic organization, chromosomal assignment and expression of a novel mosaic serine proteinase epitheliasin
FEBS Lett.
468
93-100
2000
Mus musculus (Q9JIQ8), Mus musculus
Sure, F.; Bertog, M.; Afonso, S.; Diakov, A.; Rinke, R.; Madej, M.G.; Wittmann, S.; Gramberg, T.; Korbmacher, C.; Ilyaskin, A.V.
Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channels gamma-subunit
J. Biol. Chem.
298
102004
2022
Homo sapiens (C9JKZ3)
Schuler, B.A.; Habermann, A.C.; Plosa, E.J.; Taylor, C.J.; Jetter, C.; Negretti, N.M.; Kapp, M.E.; Benjamin, J.T.; Gulleman, P.; Nichols, D.S.; Braunstein, L.Z.; Hackett, A.; Koval, M.; Guttentag, S.H.; Blackwell, T.S.; Webber, S.A.; Banovich, N.E.; Banovich, N.E.; Banovich, N.E.; Kropski, J.A.; Sucre, J.M.
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium
J. Clin. Invest.
131
e140766
2021
Homo sapiens (C9JKZ3), Mus musculus
Ohnishi, T.; Nakamura, T.; Shima, K.; Noguchi, K.; Chiba, N.; Matsuguchi, T.
Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J. Oral Biosci.
64
229-236
2022
Homo sapiens (C9JKZ3)
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