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Literature summary for 3.4.21.122 extracted from
- Neurovirulent murine coronavirus JHM.SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion (2017), J. Virol., 91, e01564 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O15393 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | overexpression of the cell surface protease TMPRSS2 greatly enhances entry of the highly neurovirulent mouse hepatitis virus strain JHM.SD to host cells. TMPRSS2 overexpression decreases mouse hepatitis virus structural protein expression, release of infectious particles, and syncytium formation, and endogenous serine protease activity does not contribute greatly to infection, while inhibition of matrix metalloproteinase and a disintegrin and metalloprotease-family zinc metalloproteases markedly decreases both entry and cell-cell fusion | Homo sapiens |
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Release 2023.1 (January 2023)
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