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Literature summary for 3.4.21.122 extracted from

  • Wen, Z.; Wu, C.; Chen, W.; Zeng, X.; Shi, J.; Ge, J.; Chen, H.; Bu, Z.
    Establishment of MDCK stable cell lines expressing TMPRSS2 and MSPL and their applications in propagating influenza vaccine viruses in absence of exogenous trypsin (2015), Biotechnol. Res. Int., 2015, 402628 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
molecular biology establishement of MDCK cell lines stably expressing TMPRSS2. The cell line stably expresses TMPRSS2 after 20 serial passages Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in MDCK cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemagglutinin precursor HA0 + H2O enzyme cleaves the heamglutinin precursor of influenza viruses recombinant vaccines Re-5, Re-6, and Re-9 Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function expression of TMPRSS2 supports multicycle growth of H5 highly pathogenic avian influenza viruses recombinant vaccines Re-5 and Re-6 and H9 avian influenza virus recombinant vaccine Re-9 in the absence of trypsin Homo sapiens