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Literature summary for 3.4.21.122 extracted from

  • Matsuyama, S.; Nagata, N.; Shirato, K.; Kawase, M.; Takeda, M.; Taguchi, F.
    Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2 (2010), J. Virol., 84, 12658-12664 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in Vero cells expressing TMPRSS2, large syncytia are induced by SARS-CoV infection. Lysosome-tropic reagents fail to inhibit, whereas the heptad repeat peptide efficiently inhibits viral entry into cells. Production of virus in TMPRSS2-expressing cells does not result in S-protein cleavage or increased infectivity of the resulting virus. TMPRSS2 needs to be expressed in the opposing (target) cell membrane to activate S protein rather than in the producer cell Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Vero cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung expression does correlate with SARS-CoV infection in the upper lobe of the lung Homo sapiens
-

Synonyms

Synonyms Comment Organism
epitheliasin
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression does correlate with SARS-CoV infection in the upper lobe of the lung additional information

General Information

General Information Comment Organism
physiological function in Vero cells expressing TMPRSS2, large syncytia are induced by SARS-CoV infection. Lysosome-tropic reagents fail to inhibit, whereas the heptad repeat peptide efficiently inhibits viral entry into cells. Production of virus in TMPRSS2-expressing cells does not result in S-protein cleavage or increased infectivity of the resulting virus. TMPRSS2 needs to be expressed in the opposing (target) cell membrane to activate S protein rather than in the producer cell Homo sapiens