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Literature summary for 3.4.21.122 extracted from

  • Bertram, S.; Dijkman, R.; Habjan, M.; Heurich, A.; Gierer, S.; Glowacka, I.; Welsch, K.; Winkler, M.; Schneider, H.; Hofmann-Winkler, H.; Thiel, V.; Poehlmann, S.
    TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium (2013), J. Virol., 87, 6150-6160 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coronavirus HCoV-229E spike protein + H2O
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 Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function proteases TMPRSS2 and HAT cleave the HCoV-229E spike protein (229E-S) and augment 229E-S-driven cell-cell fusion. Engineered expression of TMPRSS2 and HAT renders 229E-S-driven virus-cell fusion insensitive to an inhibitor of cathepsin L. Activation by TMPRSS2 rescues 229E-S-dependent cell entry from inhibition by interferon-inducible host cell IFITM proteins. TMPRSS2 is coexpressed with CD13, the HCoV-229E receptor, in human airway epithelial cells, and CD13+ TMPRSS2+ cells are preferentially targeted by HCoV-229E Homo sapiens