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Literature summary for 3.4.21.122 extracted from

  • Reinke, L.M.; Spiegel, M.; Plegge, T.; Hartleib, A.; Nehlmeier, I.; Gierer, S.; Hoffmann, M.; Hofmann-Winkler, H.; Winkler, M.; Poehlmann, S.
    Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2 (2017), PLoS ONE, 12, e0179177 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell and COS-7 cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information residue R667 of SARS spike protein, a trypsin cleavage site, is also required for S protein cleavage by TMPRSS2. TMPRSS2 and trypsin proteases cleave different SARS S glycoforms. R667 is required for SARS S cleavage by TMPRSS2, but is dispensable for TMPRSS2-mediated S protein activation. Residue R797, reported to be required for SARS S activation by trypsin, is dispensable for S protein cleavage but required for S protein activation by TMPRSS2 Homo sapiens ?
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SARS coronavirus spike protein + H2O
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 Homo sapiens ?
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