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Literature summary for 3.4.21.122 extracted from

  • Yu, Y.; Herrmann, A.; Thonn, V.; Cordsmeier, A.; Neurath, M.; Ensser, A.; Becker, C.
    SMYD2 inhibition downregulates TMPRSS2 and decreases SARS-CoV-2 infection in human intestinal and airway epithelial cells (2022), Cells, 11, 1262 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-

Synonyms

Synonyms Comment Organism
TMPRSS2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens deficiency or pharmacological inhibition of the cellular lysine-methyltransferase SMYD2 decreases TMPRSS2 expression on both mRNA and protein levels down

General Information

General Information Comment Organism
physiological function SARS-CoV-2 uses TMPRSS2 for priming its spike protein to infect target cells. SMYD2 inhibition downregulates TMPRSS2 and blocks viral replication Homo sapiens