Literature summary for 3.4.21.122 extracted from

Boettcher, E.; Matrosovich, T.; Beyerle, M.; Klenk, H.D.; Garten, W.; Matrosovich, M.
Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium (2006), J. Virol., 80, 9896-9898 .

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Application

Application	Comment	Organism
medicine	cotransfection of mammalian cells with plasmids encoding hemagglutinin of influenza viruses and protease TMPRSS2 or human airway trypsin-like protease HAT results in hemagglutinin cleavage in situ. Transient expression of either protease in MDCK cells enables multicycle replication of influenza viruses in these cells in the absence of exogenous trypsin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelium	airway epithelium	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hemagglutinin precursor HA0 + H2O	-	Homo sapiens	hemagglutinin HA1 + hemagglutinin HA2	-	?

General Information

General Information	Comment	Organism
physiological function	cotransfection of mammalian cells with plasmids encoding hemagglutinin of influenza viruses and protease TMPRSS2 or HAT results in hemagglutinin cleavage in situ. Transient expression of either protease in MDCK cells enables multicycle replication of influenza viruses in these cells in the absence of exogenous trypsin	Homo sapiens

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Release 2023.1 (January 2023)