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Literature summary for 3.4.21.122 extracted from
- Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channels gamma-subunit (2022), J. Biol. Chem., 298, 102004 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| gamma-subunit of epithelial sodium channel + H2O | Homo sapiens | proteolytically activates the epithelial sodium channel (ENaC) by cleaving the gamma-subunit of the channel | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | C9JKZ3 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| gamma-subunit of epithelial sodium channel + H2O | proteolytically activates the epithelial sodium channel (ENaC) by cleaving the gamma-subunit of the channel | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TMPRSS2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | TMPRSS2 knockdown in cultured human airway epithelial cells (H441) reduces baseline proteolytic activation of endogenously expressed epithelial sodium channel (ENaC) | Homo sapiens |
| physiological function | TMPRSS2 is likely to contribute to proteolytic epithelial sodium channel (ENaC) activation in epithelial tissues in vivo | Homo sapiens |
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