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Literature summary for 3.4.21.122 extracted from

  • Chen, Z.; Song, X.; Li, Q.; Xie, L.; Guo, T.; Su, T.; Tang, C.; Chang, X.; Liang, B.; Huang, D.
    Androgen receptor-activated enhancers simultaneously regulate oncogene TMPRSS2 and lncRNA PRCAT38 in prostate cancer (2019), Cells, 8, 864 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
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Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
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 Homo sapiens
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VCaP cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function the knockout of androgen receptor-activated enhancers E1 or E2 simultaneously impairs the transcription of long noncoding RNA prostate cancer-associated transcript PRCAT38 and TMPRSS2 and inhibits cell growth and migration. E1 and E2 show chromatin looping with the promoters for PRCAT38 and TMPRSS2. The loop formation and enhancer activity are mediated by AR/FOXA1 binding and the activity of acetyltransferase p300 Homo sapiens