Literature summary for 3.4.21.122 extracted from

Heurich, A.; Hofmann-Winkler, H.; Gierer, S.; Liepold, T.; Jahn, O.; Poehlmann, S.
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein (2014), J. Virol., 88, 1293-1307 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293T and Cos-7 cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin-converting enzyme 2 + H2O	-	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	ACE2 processing by TMPRSS2 or HAT is required for augmentation of SARS-S-driven entry. In contrast, ACE2 cleavage is dispensable for activation of the viral S protein. Expression of TMPRSS2 increases cellular uptake of soluble SARS-S. TMPRSS2 competes with the metalloprotease ADAM17 for ACE2 processing, but only cleavage by TMPRSS2 results in augmented SARS-S-driven entry	Homo sapiens

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Release 2023.1 (January 2023)