Cloned (Comment) | Organism |
---|---|
expression in HEK-293T cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S441A | inactive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15393 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar epithelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin-converting enzyme ACE2 + H2O | - |
Homo sapiens | ? | - |
? | |
SARS coronavirus spike protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
transmembrane protease/serine subfamily member 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | angiotensin-converting enzyme ACE2 and TMPRSS2 colocalize on cell surfaces and enhance the cell entry of both SARS S-pseudotyped HIV and authentic SARS-CoV. Enhanced entry correlates with TMPRSS2-mediated proteolysis of both S protein and ACE2 | Homo sapiens |