Literature summary for 3.4.21.122 extracted from

Boettcher, E.; Freuer, C.; Steinmetzer, T.; Klenk, H.D.; Garten, W.
MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition (2009), Vaccine, 27, 6324-6329 .

Search for more literature for 3.4.21.122

Application

Application	Comment	Organism
medicine	MDCK cells with inducible expression of either TMPRSS2 or protease HAT cells support growth of human and avian influenza viruses of different subtypes in the absence of exogenous trypsin. Multicycle viral replication in both cell lines is markedly suppressed in the presence of serine protease inhibitors	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in MDCK cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

General Information

General Information	Comment	Organism
physiological function	MDCK cells with inducible expression of either TMPRSS2 or protease HAT support growth of human and avian influenza viruses of different subtypes in the absence of exogenous trypsin. Multicycle viral replication in both cell lines is markedly suppressed in the presence of serine protease inhibitors	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)