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Literature summary for 3.4.21.122 extracted from

  • Bertram, S.; Heurich, A.; Lavender, H.; Gierer, S.; Danisch, S.; Perin, P.; Lucas, J.M.; Nelson, P.S.; Poehlmann, S.; Soilleux, E.J.
    Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts (2012), PLoS ONE, 7, e35876 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.122

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell Sus scrofa
expression in HEK-293T cell Homo sapiens
expression in HEK-293T cell Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-
Mus musculus Q9JIQ8
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell TMPRSS2 is expressed by epithelial cells at all sites examined in the aerodigestive tracts as well as by many endothelial cells Homo sapiens
-
leukocyte including alveolar macrophages Homo sapiens
-
myocyte of blood vessels Homo sapiens
-
pneumocyte
-
 Homo sapiens
-
smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemagglutinin precursor HA0 + H2O
-
 Sus scrofa hemagglutinin HA1 + ?
-
 ?
hemagglutinin precursor HA0 + H2O
-
 Homo sapiens hemagglutinin HA1 + ?
-
 ?
hemagglutinin precursor HA0 + H2O
-
 Mus musculus hemagglutinin HA1 + ?
-
 ?
SARS coronavirus spike protein + H2O
-
 Sus scrofa ?
-
 ?
SARS coronavirus spike protein + H2O
-
 Homo sapiens ?
-
 ?
SARS coronavirus spike protein + H2O
-
 Mus musculus ?
-
 ?

General Information

General Information Comment Organism
physiological function both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Coexpression of ACE2 and TMPRSS2 is frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Activation of influenza virus is conserved between human, avian and porcine TMPRSS2 Sus scrofa
physiological function both proteases HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Coexpression of ACE2 and TMPRSS2 is frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Activation of influenza virus is conserved between human, avian and porcine TMPRSS2 Homo sapiens