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Literature summary for 3.4.21.122 extracted from

  • Limburg, H.; Harbig, A.; Bestle, D.; Stein, D.A.; Moulton, H.M.; Jaeger, J.; Janga, H.; Hardes, K.; Koepke, J.; Schulte, L.; Koczulla, A.R.; Schmeck, B.; Klenk, H.D.; Boettcher-Friebertshaeuser, E.
    TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes (2019), J. Virol., 93, e00649 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
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Source Tissue

Source Tissue Comment Organism Textmining
Calu-3 cell
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 Homo sapiens
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epithelial cell primary human bronchial epithelial cell and primary type II alveolar epithelial cell Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemagglutinin precursor HA0 + H2O hemagglutinin of influenza A virus and of influenza B virus Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function knockdown of active TMPRSS2 using a phosphorodiamidate morpholino oligomer that interferes with splicing of TMPRSS2 pre-mRNA prevents proteolytic activation and multiplication of influenza virus H7N9 IAV in Calu-3 cells and viruses H1N1pdm, H7N9, and H3N2 IAV in primary human bronchial epithelial cells and primary type II alveolar epithelial cells. Phosphorodiamidate morpholino oligomer treatment also inhibits the activation and spread of influenza B virus in primary type II alveolar epithelial cells but does not affect influenza B virus activation in primary human bronchial epithelial cells and Calu-3 cells Homo sapiens