Literature summary for 3.4.21.122 extracted from

Paoloni-Giacobino, A.; Chen, H.; Peitsch, M.C.; Rossier, C.; Antonarakis, S.E.
Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3 (1997), Genomics, 44, 309-320 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
modeling of structure	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	type II transmembrane protein	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	sequence conatins potential N-glycosylation sites N213 and N249	Homo sapiens
proteolytic modification	the amino-terminal Ile of the protease domain is preceded by Arg in the context of a peptide sequence Arg-Ile-Val-Gly-Gly typical for the proteolytic activator site of serine protease zymogens	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
small intestine	strong expression	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	TMPRSS2 is predicted to cleave after Lys or Arg residues since it contains Asp435 at the base of the specificity pocket (S1 subsite) that binds to the substrate	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	predicted protein of 492 amino acids that contains a serine protease domain (aa 255-492) of the S1 family that probably cleaves at Arg or Lys residues, a scavenger receptor cysteine-rich domain (aa 149-242) of group A (6 conserved Cys), a LDL receptor class A domain (aa 113-148) that may form a site for calcium and a predicted transmembrane domain (aa 84-106). The active site residues are His296, Asp345, and Ser441	Homo sapiens

Synonyms

Synonyms	Comment	Organism
TMPRSS2	-	Homo sapiens

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Release 2023.1 (January 2023)