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Literature summary for 3.4.21.122 extracted from
- Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2 (2011), J. Virol., 85, 1554-1562 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | TMPRSS2 mutants lacking exon 4 or exon 5 are devoid of enzymatic activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O15393 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Calu-3 cell | isoforms TMPRSS2 and TMPRSS4, but not HAT, are expressed in Calu-3 cells | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TMPRSS2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | treatment of cells with a peptide-conjugated phosphorodiamidate morpholino oligomer designed to interfere with TMPRSS2 pre-mRNA splicing results in TMPRSS2 mRNA lacking exon 5 and consequently the expression of a truncated and enzymatically inactive form of TMPRSS2. Altered splicing of TMPRSS2 mRNA by the peptide-conjugated phosphorodiamidate morpholino oligomer prevents hemagglutinin cleavage in different human seasonal and pandemic influenza A viruses and suppresses viral titers by 2 to 3 log10 units | Homo sapiens |
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Release 2023.1 (January 2023)
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