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Literature summary for 3.4.21.122 extracted from

  • Esumi, M.; Ishibashi, M.; Yamaguchi, H.; Nakajima, S.; Tai, Y.; Kikuta, S.; Sugitani, M.; Takayama, T.; Tahara, M.; Takeda, M.; Wakita, T.
    Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection (2015), Hepatology, 61, 437-446 .
    View publication on PubMed
Search for more literature for 3.4.21.122

Cloned(Commentary)

Cloned (Comment) Organism
expression in Huh7-25-CD81 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
S441A inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification autocleavage of TMPRSS2 releases a 24-kDa peptide from the C-terminal active domain Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-FSR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-FSR + 7-amino-4-methylcoumarin
-
 ?
Boc-QAR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-QAR 7-amino-4-methylcoumarin
-
 ?
Boc-QGR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-QGR + 7-amino-4-methylcoumarin
-
 ?
Boc-RVRR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-RVRR + 7-amino-4-methylcoumarin
-
 ?

Expression

Organism Comment Expression
Homo sapiens expression is upregulated in livers with high hepatitis C virus loads up

General Information

General Information Comment Organism
physiological function Huh7-25-CD81 cell clones stably expressing TMPRSS2- wild-type and inactive TMPRSS2-mutant genes show positive and negative enhancement of their susceptibility to cell-culture-derived hepatitis C virus infection, respectively. The cell-surface protease activity of TMPRSS2-wild-type cells is markedly active in the cleavage of peptides QAR and QGR Homo sapiens