Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.122 extracted from

  • Zmora, P.; Moldenhauer, A.S.; Hofmann-Winkler, H.; Poehlmann, S.
    TMPRSS2 isoform 1 activates respiratory viruses and is expressed in viral target cells (2015), PLoS ONE, 10, e0138380 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.122

Inhibitors

Inhibitors Comment Organism Structure
camostat mesylate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393 isoform 1
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme is autocatalytically activitated Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney robust expression of isoform 1 Homo sapiens
-
liver robust expression of isoform 1 Homo sapiens
-
lung the mRNA encoding a TMPRSS2 isoform with an extended N-terminal cytoplasmic domain (isoform 1) is expressed in lung-derived cell lines and tissues Homo sapiens
-
additional information no expression of isoform 1 in heart and brain Homo sapiens
-
muscle reduced expression of isoform 1 Homo sapiens
-
pancreas robust expression of isoform 1 Homo sapiens
-
placenta reduced expression of isoform 1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemagglutinin precursor HA0 + H2O
-
 Homo sapiens ?
-
 ?
MERS coronavirus spike protein + H2O
-
 Homo sapiens ?
-
 ?
SARS coronavirus spike protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 57700, isoform 1, and x * 53900, isoform 2, calculated from sequence Homo sapiens

General Information

General Information Comment Organism
physiological function TMPRSS2 isoform 1 colocalizes with influenza A virus hemagglutinin and cleaves and activates hemagglutinin. Isoform 1 activates the SARS-CoV spike protein for cathepsin L-independent entry into target cells Homo sapiens