Literature summary for 3.4.21.122 extracted from

Shirato, K.; Kawase, M.; Matsuyama, S.
Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2 (2013), J. Virol., 87, 12552-12561 .

Search for more literature for 3.4.21.122

Application

Application	Comment	Organism
medicine	Vero cells constitutively expressing TMPRSS2 show larger syncytia at 18 h after infection with Middle East respiratory syndrome coronavirus MERS-CoV than after infection with other coronaviruses. The susceptibility of Vero-TMPRSS2 cells to MERS-CoV is 100fold higher than that of non-TMPRSS2-expressing parental Vero cells. Simultaneous treatment with inhibitors of cathepsin L and TMPRSS2 completely blocks virus entry into Vero-TMPRSS2 cells. A single camostat treatment suppresses MERS-CoV entry into human bronchial submucosal gland-derived Calu-3 cells by 10fold and virus growth by 270fold	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Vero cell	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
camostat	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

General Information

General Information	Comment	Organism
physiological function	Vero cells constitutively expressing TMPRSS2 show larger syncytia at 18 h after infection with Middle East respiratory syndrome coronavirus MERS-CoV than after infection with other coronaviruses. The susceptibility of Vero-TMPRSS2 cells to MERS-CoV is 100fold higher than that of non-TMPRSS2-expressing parental Vero cells. Simultaneous treatment with inhibitors of cathepsin L and TMPRSS2 completely blocks virus entry into Vero-TMPRSS2 cells. A single camostat treatment suppresses MERS-CoV entry into human bronchial submucosal gland-derived Calu-3 cells by 10fold and virus growth by 270fold	Homo sapiens

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Release 2023.1 (January 2023)