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Literature summary for 3.4.21.122 extracted from
- Clinical isolates of human coronavirus 229E bypass the endosome for cell entry (2016), J. Virol., 91, e01387 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | clinical isolates of human coronavirus HCoV-229E are less likely to utilize cathepsin L for host cell entry. rather, they show a preference for TMPRSS2. Amino acid substitutions R642M and N714K in the S protein of HCoV-229E clinical isolates alter their sensitivity to a cathepsin L inhibitor. After 20 passages in HeLa cells, the ability of the isolate to use cathepsin increases, caused by amino acid substitution I577S in the S protein | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O15393 | - |
- |
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Release 2023.1 (January 2023)
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