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Literature summary for 3.4.21.122 extracted from
- TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection (2019), J. Virol., 93, e01815 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9JIQ8 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | after experimental infectionusing MERS coronavirus, TMPRSS2-deficient mouse strains show reduced body weight loss and viral kinetics in the lungs. Lack of TMPRSS2 affects the primary sites of infection and virus spread within the airway, accompanied by less severe immunopathology. TMPRSS2-KO mice show weakened inflammatory chemokine and/or cytokine responses to intranasal stimulation with poly(IC), a Toll-like receptor 3 agonist | Mus musculus |
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Release 2023.1 (January 2023)
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