Literature summary for 3.4.21.122 extracted from

Gierer, S.; Bertram, S.; Kaup, F.; Wrensch, F.; Heurich, A.; Kraemer-Kuehl, A.; Welsch, K.; Winkler, M.; Meyer, B.; Drosten, C.; Dittmer, U.; von Hahn, T.; Simmons, G.; Hofmann, H.; Poehlmann, S.
The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies (2013), J. Virol., 87, 5502-5511 .

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Application

Application	Comment	Organism
medicine	the spike protein of the human coronavirus EMC does not use known coronavirus receptors for host cell entry. TMPRSS2 activates the spike protein of human coronavirus EMC for cathepsin B/L-independent host cell entry. The serum from a human coronavirus EMC-infected patient contains neutralizing antibodies	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293T cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
coronavirus hCoV-EMC S-protein + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)