Literature summary for 3.4.21.122 extracted from

Bertram, S.; Glowacka, I.; Mueller, M.A.; Lavender, H.; Gnirss, K.; Nehlmeier, I.; Niemeyer, D.; He, Y.; Simmons, G.; Drosten, C.; Soilleux, E.J.; Jahn, O.; Steffen, I.; Poehlmann, S.
Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease (2011), J. Virol., 85, 13363-13372 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15393	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SARS coronavirus spike protein + H2O	-	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	TMPRSS2 cleaves SARS-spike protein S at multiple sites and activates SARS-S only in trans. TMPRSS2 expression renders SARS-S-driven virus-cell fusion independent of cathepsin activity	Homo sapiens

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Release 2023.1 (January 2023)