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Literature summary for 3.4.21.122 extracted from

  • Ko, C.J.; Huang, C.C.; Lin, H.Y.; Juan, C.P.; Lan, S.W.; Shyu, H.Y.; Wu, S.R.; Hsiao, P.W.; Huang, H.P.; Shun, C.T.; Lee, M.S.
    Androgen-induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasis (2015), Cancer Res., 75, 2949-2960 .
    View publication on PubMed
Search for more literature for 3.4.21.122

Application

Application Comment Organism
medicine the ability of TMPRSS2 to promote prostate cancer tumor growth and metastasis is associated with increased matriptase activation and enhanced degradation of extracellular matrix nidogen-1 and laminin beta1 in tumor xenografts Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland cancer cell higher levels of TMPRSS2 expression correlate with higher levels of matriptase activation in prostate cancer tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
laminin beta1 + H2O
-
 Homo sapiens ?
-
 ?
MASP matriptase + H2O
-
 Homo sapiens ?
-
 ?
additional information no substrate: laminin gamma1 Homo sapiens ?
-
 ?
nidogen-1 + H2O
-
 Homo sapiens ?
-
 ?

Expression

Organism Comment Expression
Homo sapiens dihydrotestosteron significantly induces the expression of TMPRSS2 protein in prostate cancer cell up

General Information

General Information Comment Organism
physiological function TMPRSS2 silencing significantly abrogates dihydrotestosteron-induced prostate cancer cell invasion Homo sapiens