Information on EC 2.3.1.15 - glycerol-3-phosphate 1-O-acyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.3.1.15
-
RECOMMENDED NAME
GeneOntology No.
glycerol-3-phosphate 1-O-acyltransferase
PATHWAY
KEGG Link
MetaCyc Link
CDP-diacylglycerol biosynthesis I
-
CDP-diacylglycerol biosynthesis II
-
Glycerolipid metabolism
-
Glycerophospholipid metabolism
-
Metabolic pathways
-
superpathway phosphatidate biosynthesis (yeast)
-
triacylglycerol biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length larger than C10.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3-glycerophosphate acyltransferase
-
-
-
-
ACP:sn-glycerol-3-phosphate acyltransferase
-
-
-
-
acyl-CoA:glycerol-3-phosphate acyltransferase 1
-
-
acyltransferase, glycerol phosphate
-
-
-
-
Ad-GPAT1
-
adenoviral GPAT1 construct
AGPAT6
-
-
AGPAT6
-
-
AGPAT6
-
-
AGPAT8
-
-
AGPAT9
-
-
alpha-glycerophosphate acyltransferase
-
-
-
-
chloroplast glycerol-3-phosphate acyltransferase
Q1PA40
-
ER-associated GPAT
-
-
glycerol 3-phosphate acyltransferase
-
-
-
-
glycerol phosphate acyltransferase
-
-
-
-
glycerol phosphate transacylase
-
-
-
-
glycerol-3-P acyltransferase 1
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
Q7XYH5
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase
P97564
-
glycerol-3-phosphate acyltransferase
Q1PA40
-
glycerol-3-phosphate acyltransferase
-
-
glycerol-3-phosphate acyltransferase 1
-
-
glycerol-3-phosphate acyltransferase 1
Q8VCT2
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase 1
P97564
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase 1
-
-
glycerol-3-phosphate acyltransferase 2
Q14DK4
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase 2
-
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase 3
Q53EU6
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase 3
Q8C0N2
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase 4
Q86UL3
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase 4
Q8K2C8
-
glycerol-3-phosphate acyltransferase 4
Q8K2C8
four isoenzymes are identified in mammals
glycerol-3-phosphate acyltransferase-1
-
-
glycerol-3-phosphate acyltransferase-1
-
-
glycerol-3-phosphate acyltransferase-like protein 1
Q14DK4
-
glycerol-3-phosphate-1 acyltransferase
P97564
-
glycerol-sn-3-phosphate acyltransferase 1
-
-
glycerophosphate acyltransferase
-
-
-
-
glycerophosphate acyltransferase
-
-
glycerophosphate transacylase
-
-
-
-
GPAM
-
-
GPAT
Q7XYH5
-
GPAT
-
-
GPAT
-
-
GPAT
-
-
GPAT
P97564
-
GPAT-1
-
-
GPAT1
-
-
GPAT1
Q8VCT2
-
GPAT1
P97564
-
GPAT2
-
-
GPAT2
-
-
GPAT2
Q14DK4
-
GPAT2
D3ZI76
-
GPAT3
-
-
GPAT3
Q53EU6
-
GPAT3
-
-
GPAT3
-
-
GPAT3
Q8C0N2
-
GPAT4
-
-
GPAT4
Q86UL3
-
GPAT4
-
-
GPAT4
-
-
GPAT4
Q8K2C8
-
GPAT8
Q5XF03
-
GPAT9
Q8GWG0
-
LPAAT-theta
-
-
mtGPAT
-
-
mtGPAT
Q61586
-
mtGPAT1
-
-
mtGPAT1
-
-
mtGPAT2
-
-
mtGPAT2
-
-
PlsY
-
uses PslX produced acyl-phosphate as acyl-residue donor
Sn-glycerol 3-phosphate acyltransferase
-
-
-
-
sn-glycerol-3-phosphate acyltransferase
-
-
sn-glycerol-3-phosphate acyltransferase
-
-
xGPAT1
-
-
xGPAT1
Q14DK4
-
xGPAT1-v1
Q14DK4
-
xGPAT1-v2
Q14DK4
-
LPAAT-zeta
-
-
additional information
-
enzyme not identical with EC 2.3.1.42
additional information
Rattus norvegicus Sprague-Dawley
-
enzyme not identical with EC 2.3.1.42
-
additional information
-
enzyme may be identical with EC 2.3.1.42
CAS REGISTRY NUMBER
COMMENTARY
9029-96-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
isoform GPAT6
-
-
Manually annotated by BRENDA team
turnip rape, var. Bele
-
-
Manually annotated by BRENDA team
sweet pepper
UniProt
Manually annotated by BRENDA team
safflower, var. Gila
-
-
Manually annotated by BRENDA team
Hartley strain, female
-
-
Manually annotated by BRENDA team
cucumber
-
-
Manually annotated by BRENDA team
cv. Shirogikuza, CmATS1,1 encoding oleate-selective isozyme AT1
SwissProt
Manually annotated by BRENDA team
cv. Shirogikuza, CmATS1,2 encoding non-selective isoforms AT2 and AT3
SwissProt
Manually annotated by BRENDA team
squash, isoenzymes AT1-3
-
-
Manually annotated by BRENDA team
oil palm
-
-
Manually annotated by BRENDA team
A324 and 205; K-12; K-12 derivative strains 8, wild-type genotype; strain 8 overproducing mutants CV15, lsA-genotype and BB 26-36, plsB-genotype
-
-
Manually annotated by BRENDA team
B; K-12
-
-
Manually annotated by BRENDA team
K-12 derivative strains 8, wild-type genotype; overproducing strains VL3/pVL1, contains hybrid plasmid bearing plsB structural gene and VL3/plB3-4
-
-
Manually annotated by BRENDA team
overproducing strains VL3/pVL1, contains hybrid plasmid bearing plsB structural gene and VL3/plB3-4
-
-
Manually annotated by BRENDA team
strain ML 308-225, i-z-y+
-
-
Manually annotated by BRENDA team
Escherichia coli 8
strain 8 overproducing mutants CV15, lsA-genotype and BB 26-36, plsB-genotype
-
-
Manually annotated by BRENDA team
Escherichia coli ML 308-225
strain ML 308-225, i-z-y+
-
-
Manually annotated by BRENDA team
var. bacillaris, achloroplastic mutant
-
-
Manually annotated by BRENDA team
Euglena sp.
-
-
-
Manually annotated by BRENDA team
single gene, no isozymes
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
Q8C0N2, Q8VCT2
UniProt
Manually annotated by BRENDA team
3 isozymes
-
-
Manually annotated by BRENDA team
precursor
SwissProt
Manually annotated by BRENDA team
avocado, cv. Fuerte
-
-
Manually annotated by BRENDA team
kidney bean
-
-
Manually annotated by BRENDA team
pea, var. kleine Rheinländerin
-
-
Manually annotated by BRENDA team
petit Provençal
-
-
Manually annotated by BRENDA team
male Harlan Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
male wistar rat
-
-
Manually annotated by BRENDA team
male; Sprague-Dawley strain
-
-
Manually annotated by BRENDA team
male; Wistar strain
-
-
Manually annotated by BRENDA team
Sprague-Dawley strain
-
-
Manually annotated by BRENDA team
Wistar strain
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley strain
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar strain
-
-
Manually annotated by BRENDA team
castor bean
-
-
Manually annotated by BRENDA team
isoform Gat1/Gpt2
SwissProt
Manually annotated by BRENDA team
possesses two GPAT
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae OC-2
OC-2
-
-
Manually annotated by BRENDA team
african locust, cv. Forskäl, male adult
-
-
Manually annotated by BRENDA team
Lycopersicon esculentum cv. Zhongshu 4
UniProt
Manually annotated by BRENDA team
spinach, var. Subito
-
-
Manually annotated by BRENDA team
var. Mona Lisa
-
-
Manually annotated by BRENDA team
var. Vital
-
-
Manually annotated by BRENDA team
WH-14, ciliated protozoon
-
-
Manually annotated by BRENDA team
var. angulispora
-
-
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
10
50
-
approx. half-maximal activity at 10°C and 50°C
20
40
-
approx. half-maximal activity at 20°C and about 70% of maximal activity at 40°C
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
docking experiments with the soluble squash chloroplast enzyme crystal structure, PDB code 1k30, and inhibitors (1S,2R,3R)-2-hydroxy-3-[(octylsulfonyl)amino]cyclopentanecarboxylic acid, (+-)-2-hydroxy-3-(octylsulfonamido)-cyclohexanecarboxylic acid, (1S,2S,3S)-2-hydroxy-3-[(octylsulfonyl)amino]cyclopentanecarboxylic acid, and (+-)-2-(2-hydroxy-3-(octylsulfonamido)-cyclopentyl)acetic acid. Cyclopentyl and cyclohexyl scaffolds of the inhibitors may be occluded from the enzyme active site by two protein loops that sterically guard the phosphate binding region
P10349
hanging-drop vapour diffusion, poly(ethylene glycol) 4000 as precipitant, 1.9 A resolution
-
purified recombinant native and selenomethionine-labeled wild-type and chimeric enzymes, 14 mg/ml protein in 20 mM sodium phosphate, pH 8.0, 4°C, hanging drop vapour diffusion method, crystallization solution contains 4-25% PEG 4000, 0.1 M ammonium acetate,10% v/v 2-propanolin 100 mM citrate, pH 5.6, X-ray diffraction structure determination and analysis at 1.55 A resolution
-
recombinant chimeric enzyme, 14 mg/ml protein in 20 mM sodium phosphate, pH 8.0, 4°C, hanging drop vapour diffusion method, crystallization solution contains 4-25% PEG 4000, 0.1 M ammonium acetate,10% v/v 2-propanolin 100 mM citrate, pH 5.6, X-ray diffraction structure determination and analysis at 1.55 A resolution
-