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Literature summary for 2.3.1.15 extracted from

  • Chen, Y.Q.; Kuo, M.S.; Li, S.; Bui, H.H.; Peake, D.A.; Sanders, P.E.; Thibodeaux, S.J.; Chu, S.; Qian, Y.W.; Zhao, Y.; Bredt, D.S.; Moller, D.E.; Konrad, R.J.; Beigneux, A.P.; Young, S.G.; Cao, G.
    AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase (2008), J. Biol. Chem., 283, 10048-10057.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
into the mammalian expression vector p3xFLAG-CMV-14 for transfection of HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
membrane
-
Homo sapiens 16020
-
microsome
-
Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate Homo sapiens
-
CoA + 1-acyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by anti-FLAG M2 affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate
-
Homo sapiens CoA + 1-acyl-sn-glycerol 3-phosphate
-
?
fatty acyl-CoA + glycerol-3-phosphate
-
Homo sapiens CoA + lysophosphatidic acid
-
?
lauroyl-CoA + glycerol-3-phosphate
-
Homo sapiens CoA + 1-lauroyl-sn-glycerol 3-phosphate
-
?
linoleoyl-CoA + glycerol-3-phosphate
-
Homo sapiens CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
?
oleoyl-CoA + glycerol-3-phosphate
-
Homo sapiens CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
?
palmitoyl-CoA + glycerol-3-phosphate
-
Homo sapiens CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
AGPAT6
-
Homo sapiens
glycerol-3-phosphate acyltransferase
-
Homo sapiens
GPAT
-
Homo sapiens
GPAT4
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
activity assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
activity assay Homo sapiens