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Literature summary for 2.3.1.15 extracted from

  • Dircks, L.K.; Ke, J.; Sul, H.S.
    A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis (1999), J. Biol. Chem., 274, 34728-34734.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E315A 28% of wild-type mitochondrial acyltransferase activity Mus musculus
E315Q 47% of wild-type mitochondrial acyltransferase activity Mus musculus
F313A 17% of wild-type mitochondrial acyltransferase activity Mus musculus
F313Y 88% of wild-type mitochondrial acyltransferase activity Mus musculus
R278H 10% of wild-type mitochondrial acyltransferase activity Mus musculus
R278K 76% of wild-type mitochondrial acyltransferase activity Mus musculus
R279A 101% of wild-type mitochondrial acyltransferase activity Mus musculus
R279H 95% of wild-type mitochondrial acyltransferase activity Mus musculus
R279K 101% of wild-type mitochondrial acyltransferase activity Mus musculus
R318H 2.6% of wild-type mitochondrial acyltransferase activity Mus musculus
R318K 11% of wild-type mitochondrial acyltransferase activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cyclohexandione 50 mM, almost complete inhibition of mitochondrial acyltransferase Mus musculus
Phenylglyoxal 50 mM, approx. 70% inhibition of mitochondrial acyltransferase Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0032
-
palmitoyl-CoA R318A mutant mitochondrial acyltransferase Mus musculus
0.0046
-
palmitoyl-CoA R318K mutant mitochondrial acyltransferase Mus musculus
0.011
-
palmitoyl-CoA wild-type mitochondrial acyltransferase Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q61586
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + sn-glycerol 3-phosphate
-
Mus musculus CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
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