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Literature summary for 2.3.1.15 extracted from

  • Lewin, T.M.; Wang, S.; Nagle, C.A.; Van Horn, C.G.; Coleman, R.A.
    Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes (2005), Am. J. Physiol., 288, E835-844.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of FLAG-tagged mitochondrial isozymes in HEK293 cells and in primary hepatocytes from fasted rats via adenovirus transfection system, leading to increased enzyme activity and incorporation of added oleate into triacylglycerol, the triacylgycerol is secreted from the recombinant hepatocytes if higher concentrated, phospholipid composition in hepatocytes, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial isozyme Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate Rattus norvegicus the enzyme catalyzes the first and committed step in the synthesis of glycerophospholipids and TAG from sn-glycerol-3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate
-
Rattus norvegicus CoA + 1-acyl-sn-glycerol 3-phosphate
-
?
acyl-CoA + sn-glycerol 3-phosphate the enzyme catalyzes the first and committed step in the synthesis of glycerophospholipids and TAG from sn-glycerol-3-phosphate Rattus norvegicus CoA + 1-acyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
glycerol-3-phosphate acyltransferase-1
-
Rattus norvegicus
mtGPAT
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus