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Literature summary for 2.3.1.15 extracted from

  • Haldar, D.; Vancura, A.
    Glycerophosphate acyltransferase from liver (1992), Methods Enzymol., 209, 64-72.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetone activation of mitochondrial enzyme, inhibition of microsomal enzyme Rattus norvegicus
asolectin i.e. crude mixture of soybean phospholipids, activation of mitochondrial enzyme Rattus norvegicus
Non-site-specific proteases activation, e.g. proteinase K, subtilisin, not chymotrypsin, trypsin, mitochondrial enzyme, degree of inhibition increases with decreasing ionic strength Rattus norvegicus
phosphatidylcholine i.e. lecithin, activation of mitochondrial enzyme Rattus norvegicus
phosphatidylethanolamine activation of microsomal enzyme Rattus norvegicus
phosphatidylserine activation of mitochondrial enzyme Rattus norvegicus
Polymyxin B activation of mitochondrial enzyme, inhibition of microsomal enzyme Rattus norvegicus
Proteases activation, microsomal enzyme Rattus norvegicus

General Stability

General Stability Organism
bovine serum albumin stabilizes Rattus norvegicus
phospholipids stabilize Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cardiolipin inhibition of mitochondrial enzyme Rattus norvegicus
diacylglycerophosphate i.e. phosphatidic acid, inhibition of mitochondrial enzyme Rattus norvegicus
iodoacetamide
-
Rattus norvegicus
Monoacylglycerophosphate i.e. lysophosphatidic acid, inhibition of mitochondrial enzyme Rattus norvegicus
additional information liver microsomal enzyme is inhibited by all proteases; liver mitochondrial enzyme, not inhibited by trypsin and chymotrypsin Rattus norvegicus
N-ethylmaleimide strong inhibition of microsomal isozyme, mitochondrial enzyme is not inhibited Rattus norvegicus
phosphatidylinositol inhibition of microsomal enzyme Rattus norvegicus
phosphatidylserine inhibition of microsomal enzyme Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1 0.2 sn-glycerol 3-phosphate microsomal enzyme Rattus norvegicus
1
-
sn-glycerol 3-phosphate mitochondrial enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
mitochondrial outer membrane spans transverse plane of outer membrane Rattus norvegicus 5741
-
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation of microsomal and mitochondrial enzyme Rattus norvegicus
Mg2+
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000 85000 mitochondrial enzyme, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate Rattus norvegicus initial reaction of phosphoglycerol biosynthesis CoA + 1-acyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
microsomal enzyme, Sepharose 2B, sucrose gradient, partial purification Rattus norvegicus
mitochondrial enzyme, Sepharose Q, BioGel HAT, octyl-Sepharose CL-4B, partial purification Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.021
-
mitochondrial enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate saturated acyl-CoAs preferred Rattus norvegicus CoA + 1-acyl-sn-glycerol 3-phosphate
-
?
acyl-CoA + sn-glycerol 3-phosphate initial reaction of phosphoglycerol biosynthesis Rattus norvegicus CoA + 1-acyl-sn-glycerol 3-phosphate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
-
Rattus norvegicus CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 80000-85000, mitochondrial enzyme, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6 9 both microsomal and mitochondrial enzymes exhibit a broad optimum Rattus norvegicus