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Literature summary for 2.3.1.15 extracted from

  • Stapleton, C.; Mashek, D.; Wang, S.; Nagle, C.; Cline, G.; Thuillier, P.; Leesnitzer, L.; Li, L.; Stimmel, J.; Shulman, G.; Coleman, R.
    Lysophosphatidic acid activates peroxisome proliferator activated receptor-gamma in CHO cells that over-express glycerol 3-phosphate acyltransferase-1 (2011), PLoS ONE, 6, e18932.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P97564
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General Information

General Information Comment Organism
physiological function upon stable overexpression of isoform Gpat1, lysophosphatidic acid levels in CHO-GPAT1 cells are 6fold higher than in wild-type CHO cells, and the mRNA abundance of CD36, a target of peroxisome proliferator activated receptor PPARgamma, is 2fold higher. PPARgamma activity is higher in the cells that overexpress isoform GPAT1. PPARgamma activity is further enhanced in CHO-GPAT1 cells treated with the PPARgamma ligand troglitazone. Extracellular LPA, phosphatidic acid or a membrane-permeable diacylglycerol have no effect Rattus norvegicus