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Literature summary for 2.3.1.15 extracted from

  • Hammond, L.E.; Albright, C.D.; He, L.; Rusyn, I.; Watkins, S.M.; Doughman, S.D.; Lemasters, J.J.; Coleman, R.A.
    Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice (2007), Exp. Mol. Pathol., 82, 210-219.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Insulin Gpat1 is upregulated by insulin Mus musculus
SREBP-1 Gpat1 is upregulated by SREBP-1 Mus musculus

Application

Application Comment Organism
medicine Gpat1-/- mouse may be a useful model in which to study novel relationships between hepatic mitochondrial dysfunction, oxidative stress, apoptosis, proliferation, and cancer susceptibility Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AMP-activated protein kinase AMP-activated protein kinase reciprocally regulates GPAT1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
Mus musculus 5741
-
mitochondrion
-
Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate Mus musculus
-
CoA + 1-acyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
liver mitochondria are prepared Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate
-
Mus musculus CoA + 1-acyl-sn-glycerol 3-phosphate
-
?
fatty acyl-CoA + glycerol-3-phosphate long-chain fatty acyl-CoA Mus musculus CoA + lysophosphatidic acid
-
?

Synonyms

Synonyms Comment Organism
glycerol-3-phosphate acyltransferase-1
-
Mus musculus