Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | Gpat1 is upregulated by insulin | Mus musculus | |
SREBP-1 | Gpat1 is upregulated by SREBP-1 | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | Gpat1-/- mouse may be a useful model in which to study novel relationships between hepatic mitochondrial dysfunction, oxidative stress, apoptosis, proliferation, and cancer susceptibility | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMP-activated protein kinase | AMP-activated protein kinase reciprocally regulates GPAT1 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | - |
Mus musculus | 5741 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + sn-glycerol 3-phosphate | Mus musculus | - |
CoA + 1-acyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
liver mitochondria are prepared | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + sn-glycerol 3-phosphate | - |
Mus musculus | CoA + 1-acyl-sn-glycerol 3-phosphate | - |
? | |
fatty acyl-CoA + glycerol-3-phosphate | long-chain fatty acyl-CoA | Mus musculus | CoA + lysophosphatidic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycerol-3-phosphate acyltransferase-1 | - |
Mus musculus |