Cloned (Comment) | Organism |
---|---|
mutant enzymes expressed in CHO cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | truncation of the C-terminal domain and characterization of the properties of the resulting mutants expressed in CHO cells. Although the mutants are overexpressed, none of them confers GPAT activity. The loss of activity is not due to the miss-targeting of the proteins. The C-terminal domain is necessary for mtGPAT1 activity, and probably contributes to catalysis or substrate binding | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | mtGPAT1 has two transmembrane domains (TMDs) (aa 472493 and aa 576592) with both the N- and C-termini facing the cytosol and a loop (aa 494575) facing the intermembrane space | Rattus norvegicus | 31966 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + sn-glycerol 3-phosphate | - |
Rattus norvegicus | CoA + 1-palmitoyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycerol-3-phosphate acyltransferase-1 | - |
Rattus norvegicus |
mtGPAT1 | - |
Rattus norvegicus |