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Literature summary for 2.3.1.15 extracted from

  • Karlsson, E.A.; Wang, S.; Shi, Q.; Coleman, R.A.; Beck, M.A.
    Glycerol-3-phosphate acyltransferase 1 is essential for the immune response to infection with coxsackievirus B3 in mice (2009), J. Nutr., 139, 779-783.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine lack of GPAT1 activity affects both innate and adaptive immune mechanisms Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
glycerol-3-phosphate acyltransferase 1
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Mus musculus
GPAT1
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Mus musculus

General Information

General Information Comment Organism
malfunction livers and hearts from mice deficient in GPAT1 (Gpat1 -/-) have a decreased content of glycerolipid intermediates and triacylglycerol, an altered composition of liver phospholipids, and elevated markers of oxidative stress. Compared with control C57BL/6 mice, infection of Gpat1 -/- mice with coxsackievirus B3 results in higher mortality, an 50% increase in heart pathology, a significant increase in liver viral titers, and a 100fold increase in heart viral titers. Heart mRNA levels for proinflammatory cytokines TNF-alpha, IL-6, and IL-1B are increased in the Gpat1-/- mice. Loss of Gpat1 also results in dysregulation of specific immune cells Mus musculus