Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.15 extracted from

  • Ganesh Bhat, B.; Wang, P.; Kim, J.H.; Black, T.M.; Lewin, T.M.; Fiedorek, F.T., Jr.; Coleman, R.A.
    Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein (1999), Biochim. Biophys. Acta, 1439, 415-423.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of mitochondrial acyltransferase in Sf21 insect cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2,3-Butanedione 5 mM, 54% and 21% inhibition of microsomal and mitochondrial acyltransferase respectively Rattus norvegicus
aminophenylboronate mixed-type inhibition of microsomal and mitochondrial acyltransferase vs. glycerol 3-phosphate Rattus norvegicus
diethyldicarbonate 0.3 mM, approx. 67% inhibition of microsomal acyltransferase, approx. 40% inhibition of mitochondrial acyltransferase, approx. 60% inhibition of recombinant mitochondrial acyltransferase, activity is restored to approx 50% by hydroxylamine Rattus norvegicus
Phenylglyoxal 1 mM, 88% and 59% inhibition of microsomal and mitochondrial acyltransferase, respectively; 1 mM, 88% and 59% inhibition of microsomal and mitochondrial acyltransferase, respectively Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus P97564
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.9
-
aminophenylboronate microsomal acyltransferase Rattus norvegicus
8.2
-
aminophenylboronate mitochondrial acyltransferase Rattus norvegicus
10.3
-
aminophenylboronate recombinant mitochondrial acyltransferase Rattus norvegicus