Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8K2C8 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
GPAT4 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | the metabolic rate of Gpat4-/- mice fed a 45% fat diet is 12% higher than controls, and core body temperature is 1ΒΊC higher. A 45% fat diet increases the Gpat4-/- brown adipose tissue expression of peroxisome proliferator-activated receptor alpha target genes, Cpt1alpha, Pgc1alpha, and Ucp1, and brown adipose tissue mitochondria oxidize oleate and pyruvate at higher rates than controls. Gpat4-/- neonatal brown adipose tissue preadipocytes differentiated to adipocytes incorporate 33% less fatty acid into triacylglycerol and 46% more into the pathway of beta-oxidation | Mus musculus |