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Literature summary for 2.3.1.15 extracted from

  • Cooper, D.E.; Grevengoed, T.J.; Klett, E.L.; Coleman, R.A.
    Glycerol-3-phosphate acyltransferase isoform-4 (GPAT4) limits oxidation of exogenous fatty acids in brown adipocytes (2015), J. Biol. Chem., 290, 15112-15120.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K2C8
-
-

Synonyms

Synonyms Comment Organism
GPAT4
-
Mus musculus

General Information

General Information Comment Organism
physiological function the metabolic rate of Gpat4-/- mice fed a 45% fat diet is 12% higher than controls, and core body temperature is 1ΒΊC higher. A 45% fat diet increases the Gpat4-/- brown adipose tissue expression of peroxisome proliferator-activated receptor alpha target genes, Cpt1alpha, Pgc1alpha, and Ucp1, and brown adipose tissue mitochondria oxidize oleate and pyruvate at higher rates than controls. Gpat4-/- neonatal brown adipose tissue preadipocytes differentiated to adipocytes incorporate 33% less fatty acid into triacylglycerol and 46% more into the pathway of beta-oxidation Mus musculus