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Literature summary for 2.3.1.15 extracted from

  • Bronnikov, G.E.; Aboulaich, N.; Vener, A.V.; Stralfors, P.
    Acute effects of insulin on the activity of mitochondrial GPAT1 in primary adipocytes (2008), Biochem. Biophys. Res. Commun., 367, 201-207.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
palmitoyl-CoA
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007
-
palmitoyl-CoA value below 0.007 mM, fixed substrate concentration: 0.002 mM glycerol-3-phosphate, without addition of insulin, Vmax: 2.4 nmol/min/mg Rattus norvegicus
0.0264
-
palmitoyl-CoA fixed substrate concentration: 0.002 mM glycerol-3-phosphate, with addition of insulin, Vmax: 14.1 nmol/min/mg Rattus norvegicus
3.9
-
glycerol 3-phosphate fixed substrate concentration: 0.08 mM palmitoyl-CoA, without addition of insulin, Vmax: 6.1 nmol/min/mg Rattus norvegicus
7.2
-
glycerol 3-phosphate fixed substrate concentration: 0.02 mM palmitoyl-CoA, with addition of insulin, Vmax: 7.2 nmol/min/mg Rattus norvegicus
16.4
-
glycerol 3-phosphate fixed substrate concentration: 0.08 mM palmitoyl-CoA, with addition of insulin, Vmax: 16.6 nmol/min/mg Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein proteolytic cleavage of isolated mitochondrial membranes and mass spectrometric peptide sequencing identify in vivo phosphorylation of serine 632 and serine 639 in mtGPAT1. These phosphorylation sites correspond to casein kinase-2 consensus sequences Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + glycerol 3-phosphate
-
Rattus norvegicus CoA + 1-palmitoyl-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
mtGPAT1
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0945
-
with addition of insulin Rattus norvegicus palmitoyl-CoA
0.126
-
without addition of insulin Rattus norvegicus palmitoyl-CoA

General Information

General Information Comment Organism
physiological function treatment of primary rat adipocytes with insulin acutely affects the activity of mtGPAT1 by increasing VMAX and KM for the substrates glycerol-3-phosphate and palmitoyl-CoA Rattus norvegicus