Reference on EC 3.3.2.10 - soluble epoxide hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wixtrom, R.N.; Hammock, B.D.
Membrane-bound and soluble-fraction epoxide hydrolases
Biochem. Pharmacol. Toxicol.
1
1-93
1985
Oryctolagus cuniculus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
-
Ota, K.; Hammock, B.D.
Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver
Science
207
1479-1481
1980
Cavia porcellus, Mus musculus, Rattus norvegicus
Waechter, F.; Merdes, M.; Bieri, F.; Staeubli, W.; Bentley, P.
Purification and characterization of a soluble epoxide hydrolase from rabbit liver
Eur. J. Biochem.
125
457-461
1982
Oryctolagus cuniculus
Wang, P.; Meijer, J.; Guengerich, F.P.
Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme
Biochemistry
21
5769-5776
1982
Homo sapiens, Rattus norvegicus
Gill, S.S.
Purification of mouse liver cytosolic epoxide hydrolase
Biochem. Biophys. Res. Commun.
112
763-769
1983
Mus musculus
Meijer, J.; Depierre, J.W.
Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Purification procedure and physiochemical characterization of the pure enzymes
Eur. J. Biochem.
148
421-430
1985
Mus musculus
Prestwich, G.D.; Hammock, B.D.
Rapid purification of cytosolic epoxide hydrolase from normal and clofibrate-treated animals by affinity chromatography
Proc. Natl. Acad. Sci. USA
82
1663-1667
1985
Mus musculus
Meijer, J.; Depierre, J.W.
Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Characterization of optimal assay conditions, substrate specificity and effects of modulators on the catalytic activity
Eur. J. Biochem.
150
7-16
1985
Mus musculus
Hammock, B.D.; Prestwich, G.D.; Loury, D.N.; Cheung, P.Y.K.; Eng, W.S.; Park, S.K.; Moody, D.E.; Silva, M.H.; Wixtrom, R.N.
Comparison of crude and affinity purified cytosolic epoxide hydrolases from hepatic tissue of control and clofibrate-fed mice
Arch. Biochem. Biophys.
244
292-309
1986
Mus musculus
Meijer, J.; DePierre, J.W.
Cytosolic epoxide hydrolase
Chem. Biol. Interact.
64
207-249
1988
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
Wixtrom, R.N.; Silva, M.H.; Hammock, B.D.
Affinity purification of cytosolic epoxide hydrolase using derivatized epoxy-activated Sepharose gels
Anal. Biochem.
169
71-80
1988
Mus musculus
Schladt, L.; Hartman, R.; Woerner, W.; Thomas, H.; Oesch, F.
Purification and characterization of rat-liver cytosolic epoxide hydrolase
Eur. J. Biochem.
176
31-37
1988
Rattus norvegicus
Schladt, L.; Thomas, H.; Hartmann, R.; Oesch, F.
Human liver cytosolic epoxide hydrolases
Eur. J. Biochem.
176
715-723
1988
Homo sapiens
Miki, I.; Shimizu, T.; Seyama, Y.; Kitamura, S.; Yamaguchi, K.; Sano, H.; Ueno, H.; Hiratsuka, A.; Watanabe, T.
Enzymic conversion of 11,12-leukotriene A4 to 11,12-dihydroxy-5,14-cis-7,9-trans-eicosatetraenoic acid. Purification of an epoxide hydrolase from the guinea pig liver cytosol
J. Biol. Chem.
264
5799-5805
1989
Cavia porcellus
Arand, M.; Wagner, H.; Oesch, F.
Asp333, Asp495, and His523 form the catalytic triad of rat soluble epoxide hydrolase
J. Biol. Chem.
271
4223-4229
1996
Rattus norvegicus
Pinot, F.; Grant, D.F.; Beetham, J.K.; Parker, A.G.; Borhan, B.; Landt, S.; Jones, A.D.; Hammock, B.D.
Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase
J. Biol. Chem.
270
7968-7974
1995
Mus musculus
Blee, E.; Schuber, F.
Occurence of fatty acid epoxide hydrolases in soybean (Glycine max)
Biochem. J.
282
711-714
1992
Glycine max
Morisseau, C.; Archelas, A.; Guitton, C.; Faucher, D.; Furstoss, R.; Baratti, J.C.
Purification and characterization of a highly enantioselective epoxide hydrolase from Aspergillus niger
Eur. J. Biochem.
263
386-395
1999
Aspergillus niger
Misawa, E.; Chan Kwo Chion, C.K.C.; Archer, I.V.; Woodland, M.P.; Zhou, N.Z.; Carter, S.F.; Widdowson, D.A.; Leak, D.J.
Characterisation of a catabolic epoxide hydrolase from a Corynebacterium sp.
Eur. J. Biochem.
253
173-183
1998
Corynebacterium sp., Corynebacterium sp. C12
Chang, C.; Gill, S.S.
Purification and characterization of an epoxide hydrolase from the peroxisomal fraction of mouse liver
Arch. Biochem. Biophys.
285
276-284
1991
Mus musculus
Halarnkar, P.P.; Nourooz-Zadeh, J.; Kuwano, E.; Jones, A.D.; Hammock, B.D.
Formation of cyclic products from the diepoxide of long-chain fatty esters by cytosolic epoxide hydrolase
Arch. Biochem. Biophys.
294
586-593
1992
Mus musculus
Nourooz-Zadeh, J.; Winder, B.S.; Dietze, E.C.; Giometti, C.S.; Tollaksen, S.L.; Hammock, B.D.
Biochemical characterization of a variant form of cytosolic epoxide hydrolase induced by parental exposure to N-ethyl-N-nitrosurea
Comp. Biochem. Physiol. C
103
207-214
1992
Mus musculus, Mus musculus ENU4
Dietze, E.C.; Magdalou, J.; Hammock, B.D.
Human and murine cytosolic epoxide hydrolase: Physical and structural properties
Int. J. Biochem.
22
461-470
1990
Homo sapiens, Mus musculus
Morisseau, C.; Beetham, J.K.; Pinot, F.; Debernard, S.; Newman, J.W.; Hammock, B.D.
Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes
Arch. Biochem. Biophys.
378
321-332
2000
Arabidopsis thaliana, cress, Homo sapiens, Mus musculus, Rattus norvegicus, Solanum tuberosum
Thomas, H.; Schladt, L.; Doehmer, J.; Knehr, M.; Oesch, F.
Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at the level of protein and mRNA
Environ. Health Perspect.
88
49-55
1990
Homo sapiens, Rattus norvegicus
Summerer, S.; Hanano, A.; Utsumi, S.; Arand, M.; Schuber, F.; Blee, E.
Stereochemical features of the hydrolysis of 9,10-epoxystearic acid catalysed by plant and mammalian epoxide hydrolases
Biochem. J.
366
471-480
2002
Rattus norvegicus
Rink, R.; Kingma, J.; Lutje Spelberg, J.H.; Janssen, D.B.
Tyrosine residues serve as proton donor in the catalytic mechanism of epoxide hydrolase from Agrobacterium radiobacter
Biochemistry
39
5600-5613
2000
Agrobacterium tumefaciens, Agrobacterium tumefaciens AD1
Gomez, G.A.; Morisseau, C.; Hammock, B.D.; Christianson, D.W.
Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Biochemistry
43
4716-4723
2004
Homo sapiens (P34913), Homo sapiens
Li, C.; Liu, Q.; Song, X.; Ding, D.; Ji, A.; Qu, Y.
Epoxide hydrolase-catalyzed resolution of ethyl 3-phenylglycidate using whole cells of Pseudomonas sp
Biotechnol. Lett.
25
2113-2116
2003
Pseudomonas sp., Pseudomonas sp. BZS21
Bellevik, S.; Zhang, J.; Meijer, J.
Brassica napus soluble epoxide hydrolase (BNSEH1)
Eur. J. Biochem.
269
5295-5302
2002
Brassica napus
Nardini, M.; Rink, R.; Janssen, D.B.; Dijkstra, B.W.
Structure and mechanism of the epoxide hydrolase from Agrobacterium radiobacter AD1
J. Mol. Catal. B
11
1035-1042
2001
Agrobacterium tumefaciens, Agrobacterium tumefaciens AD1
-
Reetz, M.T.; Torre, C.; Eipper, A.; Lohmer, R.; Hermes, M.; Brunner, B.; Maichele, A.; Bocola, M.; Arand, M.; Cronin, A.; Genzel, Y.; Archelas, A.; Furstoss, R.
Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution
Org. Lett.
6
177-180
2004
Aspergillus niger
Edqvist, J.; Farbos, I.
A germination-specific epoxide hydrolase from Euphorbia lagascae
Planta
216
403-412
2003
Euphorbia lagascae
Newman, J.W.; Morisseau, C.; Harris, T.R.; Hammock, B.D.
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
Proc. Natl. Acad. Sci. USA
100
1558-1563
2003
Homo sapiens
Bellevik, S.; Summerer, S.; Meijer, J.
Overexpression of Arabidopsis thaliana soluble epoxide hydrolase 1 in Pichia pastoris and characterisation of the recombinant enzyme
Protein Expr. Purif.
26
65-70
2002
Arabidopsis thaliana
Zou, J.; Hallberg, B.M.; Bergfors, T.; Oesch, F.; Arand, M.; Mowbray, S.L.; Jones, T.A.
Structure of Aspergillus niger epoxide hydrolase at 1.8 A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases
Structure Fold. Des.
8
111-122
2000
Aspergillus niger (Q9UR30), Aspergillus niger, Aspergillus niger LCP521 (Q9UR30)
Monfort, N.; Archelas, A.; Furstoss, R.
Enzymatic transformations. Part 55: Highly productive epoxide hydrolase catalyzed resolution of an azole antifungal key synthon
Tetrahedron
60
601-605
2004
Aspergillus niger
-
DuTeaux, S.B.; Newman, J.W.; Morisseau, C.; Fairbairn, E.A.; Jelks, K.; Hammock, B.D.; Miller, M.G.
Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism
Toxicol. Sci.
78
187-195
2004
Rattus norvegicus
Yu, Z.; Davis, B.B.; Morisseau, C.; Hammock, B.D.; Olson, J.L.; Kroetz, D.L.; Weiss, R.H.
Vascular localization of soluble epoxide hydrolase in the human kidney
Am. J. Physiol.
286
F720-726
2004
Homo sapiens
Shin, J.H.; Engidawork, E.; Delabar, J.M.; Lubec, G.
Identification and characterization of soluble epoxide hydrolase in mouse brain by a robust protein biocehmical method
Amino Acids
28
63-69
2005
Mus musculus (P34914), Mus musculus
Jones, P.D.; Wolf, N.M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B.D.
Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies
Anal. Biochem.
343
66-75
2005
Homo sapiens, Mus musculus
Morisseau, C.; Hammock, B.D.
Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles
Annu. Rev. Pharmacol. Toxicol.
45
311-333
2005
Homo sapiens, Mus musculus, Rattus norvegicus
Morisseau, C.; Du, G.; Newman, J.W.; Hammock, B.D.
Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives
Arch. Biochem. Biophys.
356
214-228
1998
Homo sapiens, Mus musculus
Srivastava, P.K.; Sharma, V.K.; Kalonia, D.S.; Grant, D.F.
Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quarternary structure
Arch. Biochem. Biophys.
427
164-169
2004
Homo sapiens
Enayetallah, A.E.; Grant, D.F.
Effects of human soluble epoxide hydrolase polymorphisms on isoprenoid phosphate hydrolysis
Biochem. Biophys. Res. Commun.
341
254-260
2006
Homo sapiens
Arand, M.; Hemmer, H.; Duerk, H.; Barattis, J.; Archelas, A.; Furstoss, R.
Cloning and molecular characterization of a soluble epoxide hydrolase from Aspergillus niger that is related to mammalian microsomal epoxide hydrolase
Biochem. J.
344
273-280
1999
Aspergillus niger (Q9UR30), Aspergillus niger LCP521 (Q9UR30)
-
Dietze, E.C.; Kuwano, E.; Casa, J.; Hammock, B.D.
Inhibition of cytosolic epoxide hydrolase by trans-3-phenylglycidols
Biochem. Pharmacol.
42
1163-1175
1991
Mus musculus
Tran, K.L.; Aronov, P.A.; Tanaka, H.; Newman, J.W.; Hammock, B.D.; Morisseau, C.
Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble poxide hydrolase
Biochemistry
44
12179-12187
2005
Homo sapiens
Lacourciere, G.M.; Armstrong, R.N.
Microsomal ans soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes
Chem. Res. Toxicol.
7
121-124
1994
Rattus norvegicus
Yu, Z.; Xu, F.; Huse, L.M.; Morisseau, C.; Draper, A.J.; Newman, J.W.; Parker, C.; Graham, L.; Engler, M.M.; Hammock, B.D.; Zeldin, D.C.; Kroetz, D.L.
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids
Circ. Res.
87
992-998
2000
Rattus norvegicus
Dietze, E.C.; Stephens, J.; Magdalou, J.; Bender, D.M.; Moyer, M.; Fowler, B.; Hammock, B.D.
Inhibition of human and murine cytosolic epoxide hydrolase by group-selective reagents
Comp. Biochem. Physiol. B
104
299-308
1993
Homo sapiens, Mus musculus
Arahira, M.; Nong, V.H.; Udaka, K.; Fukazawa, C.
Purification, molecular cloning and ethylene-inducible expression of a soluble-type epoxide hydrolase from soybean (Glycine max [L.] Merr.)
Eur. J. Biochem.
267
2649-2657
2000
Glycine max (O49857), Glycine max
Sellers, K.W.; Sun, C.; Diez-Freire, C.; Waki, H.; Morisseau, C.; Falck, J.R.; Hammock, B.D.; Paton, J.F.; Raizada, M.K.
Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat
FASEB J.
19
626-628
2005
Rattus norvegicus
Mullen, R.T.; Trelease, R.N.; Duerk, H.; Arand.M.; Hammock, B.D.; Oesch, F.; Grant, D.F.
Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants
FEBS Lett.
445
301-305
1999
Mus musculus, Rattus norvegicus
Dietze, E.D.; Kuwano, E.; Hammock, B.D.
The interaction of cytosolic epoxide hydrolase with chiral epoxides
Int. J. Biochem.
25
43-52
1993
Mus musculus
Schiott, B.; Bruice, T.C.
Reaction mechanism of soluble epoxide hydrolase: insights from molecular dynamics simulations
J. Am. Chem. Soc.
124
14558-14570
2002
Mus musculus (P34914)
Haeggstroem, J.; Meijer, J.; Radmark, O.
Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase
J. Biol. Chem.
261
6332-6337
1986
Mus musculus
Enayetallah, A.E.; French, R.A.; Barber, M.; Grant, D.F.
Cell-specific subcellular localization of soluble epoxide hydrolase in human tissues
J. Histochem. Cytochem.
54
329-335
2006
Homo sapiens
McElroy, N.R.; Jurs, P.C.
QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds
J. Med. Chem.
46
1066-1080
2003
Homo sapiens, Mus musculus
Stapleton, A.; Beetham, J.K.; Pinot, F.; Garbarino, J.E.; Rockhold, D.R.; Friedman, M.; Hammock, B.D.; Belknap, W.R.
Cloning and expression of soluble epoxide hydrolase from potato
Plant J.
6
251-258
1994
Solanum tuberosum, no activity in Trichoplusia ni
Harris, T.R.; Morisseau, C.; Walzem, R.L.; Ma, S.J.; Hammock, B.D.
The cloning and characterization of a soluble epoxide hydrolase in chicken
Poult. Sci.
85
278-287
2006
Gallus gallus (Q45QT1), Gallus gallus
Cronin, A.; Mowbray, S.; Duerk, H.; Homburg, S.; Fleming, I.; Fisslthaler, B.; Oesch, F.; Arand, M.
The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
Proc. Natl. Acad. Sci. USA
100
1552-1557
2003
Homo sapiens, Rattus norvegicus, Mus musculus (P34914)
Schmelzer, K.R.; Kubala, L.; Newman, J.W.; Kim, I.H.; Eiserich, J.P.; Hammock, B.D.
Soluble epoxide hydrolase is a therapeutic target for acute inflammation
Proc. Natl. Acad. Sci. USA
102
9772-9777
2005
Mus musculus
Newman, J.W.; Morisseau, C.; Hammock, B.D.
Epoxide hydrolases: their roles and interactions with lipid metabolism
Prog. Lipid Res.
44
1-51
2005
Ananas comosus, Apium graveolens, Arabidopsis thaliana, Brassica napus, Cavia porcellus, Citrus jambhiri, Equus caballus, Euphorbia lagascae, Glycine max, Homo sapiens, Macaca mulatta, Malus pumila, Mesocricetus auratus, Mus musculus (P34914), Nicotiana tabacum, Oncorhynchus mykiss, Oryctolagus cuniculus, Oryza sativa, Oryzias latipes, Papio sp., Pimephales promelas, Rattus norvegicus, Ricinus communis, Solanum tuberosum, Spinacia oleracea, Stenotomus chrysops, Sus scrofa, Triticum aestivum, Vicia sativa, Zea mays
Gomez, G.A.; Morisseau, C.; Hammock, B.D.; Christianson, D.W.
Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci.
15
58-64
2006
Homo sapiens (P34913), Homo sapiens
Draper, A.J.; Hammock, B.D.
Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals
Toxicol. Sci.
52
26-32
1999
Homo sapiens, Mus musculus, Rattus norvegicus, Solanum tuberosum
Gong, P.F.; Xu, J.H.; Tang, Y.F.; Wu, H.Y.
Improved catalytic performance of Bacillus megaterium epoxide hydrolase in a medium containing Tween-80
Biotechnol. Prog.
19
652-654
2003
Priestia megaterium, Priestia megaterium ECU1001
Enayetallah, A.E.; French, R.A.; Grant, D.F.
Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9, and 2J2 in human malignant neoplasms
J. Mol. Histol.
37
133-141
2006
Homo sapiens
Wolf, N.M.; Morisseau, C.; Jones, P.D.; Hock, B.; Hammock, B.D.
Development of a high-throughput screen for soluble epoxide hydrolase inhibition
Anal. Biochem.
355
71-80
2006
Homo sapiens
Labitzke, E.M.; Diani-Moore, S.; Rifkind, A.B.
Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase
Arch. Biochem. Biophys.
468
70-81
2007
Gallus gallus
Kim, I.H.; Nishi, K.; Tsai, H.J.; Bradford, T.; Koda, Y.; Watanabe, T.; Morisseau, C.; Blanchfield, J.; Toth, I.; Hammock, B.D.
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase
Bioorg. Med. Chem.
15
312-323
2007
Homo sapiens
Jones, P.D.; Tsai, H.J.; Do, Z.N.; Morisseau, C.; Hammock, B.D.
Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase
Bioorg. Med. Chem. Lett.
16
5212-5216
2006
Homo sapiens (P34913), Homo sapiens
Hwang, S.; Choi, C.Y.; Lee, E.Y.
Enantioconvergent bioconversion of p-chlorostyrene oxide to (R)-p-chlorophenyl-1,2-ethandiol by the bacterial epoxide hydrolase of Caulobacter crescentus
Biotechnol. Lett.
30
1219-1225
2008
Caulobacter vibrioides
Seubert, J.M.; Sinal, C.J.; Graves, J.; DeGraff, L.M.; Bradbury, J.A.; Lee, C.R.; Goralski, K.; Carey, M.A.; Luria, A.; Newman, J.W.; Hammock, B.D.; Falck, J.R.; Roberts, H.; Rockman, H.A.; Murphy, E.; Zeldin, D.C.
Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
Circ. Res.
99
442-450
2006
Mus musculus
Koerner, I.P.; Zhang, W.; Cheng, J.; Parker, S.; Hurn, P.D.; Alkayed, N.J.
Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia
Front. Biosci.
13
2833-2841
2008
Rattus norvegicus
Chiappe, C.; Leandri, E.; Hammock, B.D.; Morisseau, C.
Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols
Green Chem.
9
162-168
2007
Mus musculus
Corenblum, M.J.; Wise, V.E.; Georgi, K.; Hammock, B.D.; Doris, P.A.; Fornage, M.
Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat
Hypertension
51
567-573
2008
Rattus norvegicus
Sura, P.; Sura, R.; Enayetallah, A.E.; Grant, D.F.
Distribution and expression of soluble epoxide hydrolase in human brain
J. Histochem. Cytochem.
56
551-559
2008
Homo sapiens
Hwang, S.H.; Tsai, H.J.; Liu, J.Y.; Morisseau, C.; Hammock, B.D.
Orally bioavailable potent soluble epoxide hydrolase inhibitors
J. Med. Chem.
50
3825-3840
2007
Canis lupus, Felis catus, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Homo sapiens (P34913), Homo sapiens
Kim, I.H.; Tsai, H.J.; Nishi, K.; Kasagami, T.; Morisseau, C.; Hammock, B.D.
1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties
J. Med. Chem.
50
5217-5226
2007
Homo sapiens
Hopmann, K.H.; Himo, F.
Insights into the reaction mechanism of soluble epoxide hydrolase from theoretical active site mutants
J. Phys. Chem. B
110
21299-21310
2006
Homo sapiens (P34913), Homo sapiens
Ai, D.; Fu, Y.; Guo, D.; Tanaka, H.; Wang, N.; Tang, C.; Hammock, B.D.; Shyy, J.Y.; Zhu, Y.
Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo
Proc. Natl. Acad. Sci. USA
104
9018-9023
2007
Bos taurus, Homo sapiens, Rattus norvegicus
Motoki, A.; Merkel, M.J.; Packwood, W.H.; Cao, Z.; Liu, L.; Iliff, J.; Alkayed, N.J.; Van Winkle, D.M.
Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo
Am. J. Physiol. Heart Circ. Physiol.
295
H2128-H2134
2008
Mus musculus
Decker, M.; Arand, M.; Cronin, A.
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
Arch. Toxicol.
83
297-318
2009
Homo sapiens, Mus musculus (P34914)
Anandan, S.K.; Do, Z.N.; Webb, H.K.; Patel, D.V.; Gless, R.D.
Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors
Bioorg. Med. Chem. Lett.
19
1066-1070
2009
Homo sapiens
Xie, Y.; Liu, Y.; Gong, G.; Smith, D.H.; Yan, F.; Rinderspacher, A.; Feng, Y.; Zhu, Z.; Li, X.; Deng, S.X.; Branden, L.; Vidovi?, D.; Chung, C.; Schuerer, S.; Morisseau, C.; Hammock, B.D.; Landry, D.W.
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase
Bioorg. Med. Chem. Lett.
19
2354-2359
2009
Homo sapiens
Liu, J.Y.; Tsai, H.J.; Hwang, S.H.; Jones, P.D.; Morisseau, C.; Hammock, B.D.
Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation
Br. J. Pharmacol.
156
284-296
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Parrish, A.R.; Chen, G.; Burghardt, R.C.; Watanabe, T.; Morisseau, C.; Hammock, B.D.
Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase
Cell Biol. Toxicol.
25
217-225
2009
Mus musculus
Olearczyk, J.J.; Quigley, J.E.; Mitchell, B.C.; Yamamoto, T.; Kim, I.H.; Newman, J.W.; Luria, A.; Hammock, B.D.; Imig, J.D.
Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats
Clin. Sci.
116
61-70
2009
Rattus norvegicus
Gross, G.J.; Nithipatikom, K.
Soluble epoxide hydrolase: a new target for cardioprotection
Curr. Opin. Investig. Drugs
10
253-258
2009
Mus musculus, Rattus norvegicus
Burdon, K.P.; Lehtinen, A.B.; Langefeld, C.D.; Carr, J.J.; Rich, S.S.; Freedman, B.I.; Herrington, D.; Bowden, D.W.
Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
Diab. Vasc. Dis. Res.
5
128-134
2008
Homo sapiens
Harris, T.R.; Aronov, P.A.; Hammock, B.D.
Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence
DNA Cell Biol.
27
467-477
2008
Strongylocentrotus purpuratus (B2MWN2), Strongylocentrotus purpuratus (B2MWN3), Strongylocentrotus purpuratus
Keserue, B.; Barbosa-Sicard, E.; Popp, R.; Fisslthaler, B.; Dietrich, A.; Gudermann, T.; Hammock, B.D.; Falck, J.R.; Weissmann, N.; Busse, R.; Fleming, I.
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response
FASEB J.
22
4306-4315
2008
Mus musculus
Li, J.; Carroll, M.A.; Chander, P.N.; Falck, J.R.; Sangras, B.; Stier, C.T.
Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension
Front. Biosci.
13
3480-3487
2008
Rattus norvegicus
EnayetAllah, A.E.; Luria, A.; Luo, B.; Tsai, H.J.; Sura, P.; Hammock, B.D.; Grant, D.F.
Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase
J. Biol. Chem.
283
36592-36598
2008
Homo sapiens, Mus musculus
Ulu, A.; Davis, B.B.; Tsai, H.J.; Kim, I.H.; Morisseau, C.; Inceoglu, B.; Fiehn, O.; Hammock, B.D.; Weiss, R.H.
Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model
J. Cardiovasc. Pharmacol.
52
314-323
2008
Homo sapiens, Mus musculus
Revermann, M.; Barbosa-Sicard, E.; Dony, E.; Schermuly, R.T.; Morisseau, C.; Geisslinger, G.; Fleming, I.; Hammock, B.D.; Brandes, R.P.
Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats
J. Hypertens.
27
322-331
2009
Rattus norvegicus
Luo, B.; Norris, C.; Bolstad, E.S.; Knecht, D.A.; Grant, D.F.
Protein quaternary structure and expression levels contribute to peroxisomal-targeting-sequence-1-mediated peroxisomal import of human soluble epoxide hydrolase
J. Mol. Biol.
380
31-41
2008
Homo sapiens (P34913), Homo sapiens
Cronin, A.; Homburg, S.; Duerk, H.; Richter, I.; Adamska, M.; Frere, F.; Arand, M.
Insights into the catalytic mechanism of human sEH phosphatase by site-directed mutagenesis and LC-MS/MS analysis
J. Mol. Biol.
383
627-640
2008
Homo sapiens (P34913), Homo sapiens
Rawal, S.; Morisseau, C.; Hammock, B.D.; Shivachar, A.C.
Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes
J. Neurosci. Res.
87
218-227
2009
Rattus norvegicus
Fife, K.L.; Liu, Y.; Schmelzer, K.R.; Tsai, H.J.; Kim, I.H.; Morisseau, C.; Hammock, B.D.; Kroetz, D.L.
Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation
J. Pharmacol. Exp. Ther.
327
707-715
2008
Mus musculus
Monti, J.; Fischer, J.; Paskas, S.; Heinig, M.; Schulz, H.; Goesele, C.; Heuser, A.; Fischer, R.; Schmidt, C.; Schirdewan, A.; Gross, V.; Hummel, O.; Maatz, H.; Patone, G.; Saar, K.; Vingron, M.; Weldon, S.M.; Lindpaintner, K.; Hammock, B.D.; Rohde, K.; Dietz, R.; Cook, S.A.; Schunck, W.H.; Luft, F.C.; Hub, H.u.b.n.
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
Nat. Genet.
40
529-537
2008
Homo sapiens, Rattus norvegicus
Morisseau, C.; Hammock, B.D.
Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical
Pest Manag. Sci.
64
594-609
2008
Homo sapiens
Zhang, L.; Ding, H.; Yan, J.; Hui, R.; Wang, W.; Kissling, G.E.; Zeldin, D.C.; Wang, D.W.
Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population
Pharmacogenet. Genomics
18
45-51
2008
Homo sapiens (P34913), Homo sapiens
Shi, D.H.; Xu, C.; Guo, B.X.; Wang, X.T.; Chen, Y.X.; Tan, R.X.
Inhibition of soluble epoxide hydrolase by extracts derived from inflammation-treating Chinese medicinal herbs
Phytother. Res.
22
1264-1268
2008
Homo sapiens
Inceoglu, B.; Jinks, S.L.; Ulu, A.; Hegedus, C.M.; Georgi, K.; Schmelzer, K.R.; Wagner, K.; Jones, P.D.; Morisseau, C.; Hammock, B.D.
Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways
Proc. Natl. Acad. Sci. USA
105
18901-18906
2008
Rattus norvegicus
Ai, D.; Pang, W.; Li, N.; Xu, M.; Jones, P.D.; Yang, J.; Zhang, Y.; Chiamvimonvat, N.; Shyy, J.Y.; Hammock, B.D.; Zhu, Y.
Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy
Proc. Natl. Acad. Sci. USA
106
564-569
2009
Mus musculus, Rattus norvegicus
Gschwendtner, A.; Ripke, S.; Freilinger, T.; Lichtner, P.; Mueller-Myhsok, B.; Wichmann, H.E.; Meitinger, T.; Dichgans, M.
Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans
Stroke
39
1593-1596
2008
Homo sapiens
Lee, S.H.; Lee, J.; Cha, R.; Park, M.H.; Ha, J.W.; Kim, S.; Kim, Y.S.
Genetic variations in soluble epoxide hydrolase and graft function in kidney transplantation
Transplant. Proc.
40
1353-1356
2008
Homo sapiens
Luria, A.; Morisseau, C.; Tsai, H.J.; Yang, J.; Inceoglu, B.; De Taeye, B.; Watkins, S.M.; Wiest, M.M.; German, J.B.; Hammock, B.D.
Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase
Am. J. Physiol. Endocrinol. Metab.
297
E375-E383
2009
Mus musculus (P34914), Mus musculus
Merkel, M.J.; Liu, L.; Cao, Z.; Packwood, W.; Young, J.; Alkayed, N.J.; Van Winkle, D.M.
Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling
Am. J. Physiol. Heart Circ. Physiol.
298
H679-H687
2010
Mus musculus (P34914)
Simpkins, A.N.; Rudic, R.D.; Roy, S.; Tsai, H.J.; Hammock, B.D.; Imig, J.D.
Soluble epoxide hydrolase inhibition modulates vascular remodeling
Am. J. Physiol. Heart Circ. Physiol.
298
H795-H806
2010
Rattus norvegicus (P80299)
Manhiani, M.; Quigley, J.E.; Knight, S.F.; Tasoobshirazi, S.; Moore, T.; Brands, M.W.; Hammock, B.D.; Imig, J.D.
Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
Am. J. Physiol. Renal Physiol.
297
F740-F748
2009
Mus musculus (P34914)
Zhang, L.N.; Vincelette, J.; Cheng, Y.; Mehra, U.; Chen, D.; Anandan, S.K.; Gless, R.; Webb, H.K.; Wang, Y.X.
Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia
Arterioscler. Thromb. Vasc. Biol.
29
1265-1270
2009
Mus musculus (P34914), Mus musculus
Revermann, M.; Schloss, M.; Barbosa-Sicard, E.; Mieth, A.; Liebner, S.; Morisseau, C.; Geisslinger, G.; Schermuly, R.T.; Fleming, I.; Hammock, B.D.; Brandes, R.P.
Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice
Arterioscler. Thromb. Vasc. Biol.
30
909-914
2010
Mus musculus (P34914)
Liu, J.Y.; Yang, J.; Inceoglu, B.; Qiu, H.; Ulu, A.; Hwang, S.H.; Chiamvimonvat, N.; Hammock, B.D.
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model
Biochem. Pharmacol.
79
880-887
2010
Mus musculus (P34914), Mus musculus
Oguro, A.; Sakamoto, K.; Suzuki, S.; Imaoka, S.
Contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth
Biol. Pharm. Bull.
32
1962-1967
2009
Homo sapiens (P34913), Homo sapiens
Shen, H.C.; Ding, F.X.; Wang, S.; Xu, S.; Chen, H.S.; Tong, X.; Tong, V.; Mitra, K.; Kumar, S.; Zhang, X.; Chen, Y.; Zhou, G.; Pai, L.Y.; Alonso-Galicia, M.; Chen, X.; Zhang, B.; Tata, J.R.; Berger, J.P.; Colletti, S.L.
Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors
Bioorg. Med. Chem. Lett.
19
3398-3404
2009
Homo sapiens (P34913), Rattus norvegicus (P80299)
Shen, H.C.; Ding, F.X.; Deng, Q.; Xu, S.; Chen, H.S.; Tong, X.; Tong, V.; Zhang, X.; Chen, Y.; Zhou, G.; Pai, L.Y.; Alonso-Galicia, M.; Zhang, B.; Roy, S.; Tata, J.R.; Berger, J.P.; Colletti, S.L.
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors
Bioorg. Med. Chem. Lett.
19
5314-5320
2009
Homo sapiens (P34913), Homo sapiens, Rattus norvegicus (P80299)
Shen, H.C.; Ding, F.X.; Deng, Q.; Xu, S.; Tong, X.; Zhang, X.; Chen, Y.; Zhou, G.; Pai, L.Y.; Alonso-Galicia, M.; Roy, S.; Zhang, B.; Tata, J.R.; Berger, J.P.; Colletti, S.L.
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors
Bioorg. Med. Chem. Lett.
19
5716-5721
2009
Homo sapiens (P34913), Homo sapiens
Taylor, S.J.; Soleymanzadeh, F.; Eldrup, A.B.; Farrow, N.A.; Muegge, I.; Kukulka, A.; Kabcenell, A.K.; De Lombaert, S.
Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase
Bioorg. Med. Chem. Lett.
19
5864-5868
2009
Homo sapiens (P34913), Homo sapiens, Rattus norvegicus (P80299)
Eldrup, A.B.; Soleymanzadeh, F.; Farrow, N.A.; Kukulka, A.; De Lombaert, S.
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase
Bioorg. Med. Chem. Lett.
20
571-575
2010
Rattus norvegicus (P80299)
Kullmann, S.; Binner, P.; Rackebrandt, K.; Huge, A.; Haltern, G.; Lankisch, M.; Fueth, R.; von Hodenberg, E.; Bestehorn, H.P.; Scheffold, T.
Variation in the human soluble epoxide hydrolase gene and risk of restenosis after percutaneous coronary intervention
BMC Cardiovasc. Disord.
9
48
2009
Homo sapiens (P34913), Homo sapiens
Mavrommatis, Y.; Ross, K.; Rucklidge, G.; Reid, M.; Duncan, G.; Gordon, M.J.; Thies, F.; Sneddon, A.; de Roos, B.
Intervention with fish oil, but not with docosahexaenoic acid, results in lower levels of hepatic soluble epoxide hydrolase with time in apoE knockout mice
Br. J. Nutr.
103
16-24
2010
Mus musculus (P34914)
Bianco, R.A.; Agassandian, K.; Cassell, M.D.; Spector, A.A.; Sigmund, C.D.
Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase
Brain Res.
1291
60-72
2009
Mus musculus (P34914), Mus musculus
Keserue, B.; Barbosa-Sicard, E.; Schermuly, R.T.; Tanaka, H.; Hammock, B.D.; Weissmann, N.; Fisslthaler, B.; Fleming, I.
Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition
Cardiovasc. Res.
85
232-240
2010
Homo sapiens (P34913), Homo sapiens, Mus musculus (P34914), Mus musculus C57BL/6 (P34914)
Qiu, H.; Li, N.; Liu, J.Y.; Harris, T.R.; Hammock, B.D.; Chiamvimonvat, N.
Soluble epoxide hydrolase inhibitors and heart failure
Cardiovasc. Ther.
29
99-111
2011
Homo sapiens, Mus musculus (P34914)
Wang, Y.X.; Ulu, A.; Zhang, L.N.; Hammock, B.
Soluble epoxide hydrolase in atherosclerosis
Curr. Atheroscler. Rep.
12
174-183
2010
Homo sapiens (P34913), Homo sapiens, Mus musculus (P34914), Rattus norvegicus (P80299)
Revermann, M.
Pharmacological inhibition of the soluble epoxide hydrolase-from mouse to man
Curr. Opin. Pharmacol.
10
173-178
2010
Mammalia
Marino, J.P.
Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery
Curr. Top. Med. Chem.
9
452-463
2009
Mus musculus (P34914)
Oguro, A.; Fujita, N.; Imaoka, S.
Regulation of soluble epoxide hydrolase (sEH) in mice with diabetes: high glucose suppresses sEH expression
Drug Metab. Pharmacokinet.
24
438-445
2009
Homo sapiens, Mus musculus (P34914)
Tsai, H.J.; Hwang, S.H.; Morisseau, C.; Yang, J.; Jones, P.D.; Kasagami, T.; Kim, I.H.; Hammock, B.D.
Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs
Eur. J. Pharm. Sci.
40
222-238
2010
Canis lupus familiaris, Homo sapiens (P34913)
Iliff, J.J.; Alkayed, N.J.
Soluble epoxide hydrolase inhibition: targeting multiple mechanisms of ischemic brain injury with a single agent
Future Neurol.
4
179-199
2009
Homo sapiens (P34913), Mus musculus (P34914), Rattus norvegicus (P80299)
Barbosa-Sicard, E.; Froemel, T.; Keserue, B.; Brandes, R.P.; Morisseau, C.; Hammock, B.D.; Braun, T.; Krueger, M.; Fleming, I.
Inhibition of the soluble epoxide hydrolase by tyrosine nitration
J. Biol. Chem.
284
28156-28163
2009
Homo sapiens (P34913), Homo sapiens, Mus musculus (P34914), Mus musculus, Mus musculus C57BL/6 (P34914)
Chaudhary, K.R.; Abukhashim, M.; Hwang, S.H.; Hammock, B.D.; Seubert, J.M.
Inhibition of soluble epoxide hydrolase by trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury
J. Cardiovasc. Pharmacol.
55
67-73
2010
Mus musculus (P34914), Mus musculus C57BL6 (P34914)
Zhang, W.; Iliff, J.J.; Campbell, C.J.; Wang, R.K.; Hurn, P.D.; Alkayed, N.J.
Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia
J. Cereb. Blood Flow Metab.
29
1475-1481
2009
Mus musculus (P34914)
Shen, H.; Ding, F.; Wang, S.; Deng, Q.; Zhang, X.; Chen, Y.; Zhou, G.; Xu, S.; Chen, H.; Tong, X.; Tong, V.; Mitra, K.; Kumar, S.; Tsai, C.; Stevenson, A.; Pai, L.; Alonso-Galicia, M.; Chen, X.; Soisson, S.; Roy, S.; Zhang, B.; Tata, J.; Berger, J.; Colle
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement
J. Med. Chem.
52
5009-5012
2009
Homo sapiens (P34913)
Falck, J.; Kodela, R.; Manne, R.; Atcha, K.; Puli, N.; Dubasi, N.; Manthati, V.; Capdevila, J.; Yi, X.; Goldman, D.; Morisseau, C.; Hammock, B.; Campbell, W.
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: Influence upon vascular relaxation and soluble epoxide hydrolase inhibition
J. Med. Chem.
52
5069-5075
2009
Bos taurus, Homo sapiens (P34913)
Eldrup, A.B.; Soleymanzadeh, F.; Taylor, S.J.; Muegge, I.; Farrow, N.A.; Joseph, D.; McKellop, K.; Man, C.C.; Kukulka, A.; De Lombaert, S.
Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase
J. Med. Chem.
52
5880-5895
2009
Homo sapiens (P34913), Homo sapiens, Rattus norvegicus (P80299)
Li, N.; Liu, J.Y.; Timofeyev, V.; Qiu, H.; Hwang, S.H.; Tuteja, D.; Lu, L.; Yang, J.; Mochida, H.; Low, R.; Hammock, B.D.; Chiamvimonvat, N.
Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches
J. Mol. Cell. Cardiol.
47
835-845
2009
Mus musculus (P34914), Mus musculus
Deng, Y.; Theken, K.N.; Lee, C.R.
Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation
J. Mol. Cell. Cardiol.
48
331-341
2010
Homo sapiens (P34913), Mus musculus (P34914)
Luo, P.; Chang, H.H.; Zhou, Y.; Zhang, S.; Hwang, S.H.; Morisseau, C.; Wang, C.Y.; Inscho, E.W.; Hammock, B.D.; Wang, M.H.
Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis
J. Pharmacol. Exp. Ther.
334
430-438
2010
Mus musculus (P34914), Mus musculus C57/BL6J (P34914)
Xie, W.; Tang, X.; Lu, Q.; Ames, R.S.; Ratcliffe, S.J.; Li, H.
Development of a high throughput cell-based assay for soluble epoxide hydrolase using BacMam technology
Mol. Biotechnol.
45
207-217
2010
Homo sapiens (P34913)
Liu, J.Y.; Park, S.H.; Morisseau, C.; Hwang, S.H.; Hammock, B.D.; Weiss, R.H.
Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo
Mol. Cancer Ther.
8
2193-2203
2009
Homo sapiens
Imig, J.D.; Hammock, B.D.
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
Nat. Rev. Drug Discov.
8
794-805
2009
Homo sapiens (P34913)
Marowsky, A.; Burgener, J.; Falck, J.R.; Fritschy, J.M.; Arand, M.
Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism
Neuroscience
163
646-661
2009
Mus musculus (P34914), Mus musculus, Mus musculus C57BL/6 (P34914)
Nishi, K.; Kim, I.H.; Ma, S.J.
Expression of the human soluble epoxide hydrolase in Escherichia coli by auto-induction for the study of high-throughput inhibition assays
Protein Expr. Purif.
69
34-38
2010
Homo sapiens (P34913), Homo sapiens
Nayeem, M.A.; Zeldin, D.C.; Boegehold, M.A.; Morisseau, C.; Marowsky, A.; Ponnoth, D.S.; Roush, K.P.; Falck, J.R.
Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
299
R325-R333
2010
Mus musculus
Koeners, M.; Wesseling, S.; Ulu, A.; Sepúlveda, R.; Morisseau, C.; Braam, B.; Hammock, B.; Joles, J.
Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats
Am. J. Physiol. Endocrinol. Metab.
300
691-698
2011
Rattus norvegicus
Zhang, D.; Ai, D.; Tanaka, H.; Hammock, B.D.; Zhu, Y.
DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism
Biochim. Biophys. Acta
1799
659-667
2010
Homo sapiens
Cronin, A.; Decker, M.; Arand, M.
Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase
J. Lipid Res.
52
712-719
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Xing, L.; McDonald, J.J.; Kolodziej, S.A.; Kurumbail, R.G.; Williams, J.M.; Warren, C.J.; ONeal, J.M.; Skepner, J.E.; Roberds, S.L.
Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening
J. Med. Chem.
54
1211-1222
2011
Homo sapiens (P34913)
Kim, I.H.; Park, Y.K.; Hammock, B.D.; Nishi, K.
Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase
J. Med. Chem.
54
1752-1761
2011
Homo sapiens
Hwang, S.H.; Wagner, K.M.; Morisseau, C.; Liu, J.Y.; Dong, H.; Wecksler, A.T.; Hammock, B.D.
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase
J. Med. Chem.
54
3037-3050
2011
Mus musculus, Homo sapiens (P34913)
Nayeem, M.A.; Zeldin, D.C.; Boegehold, M.A.; Falck, J.R.
Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase
Mol. Cell. Biochem.
350
101-111
2011
Mus musculus
De Taeye, B.; Morisseau, C.; Coyle, J.; Covington, J.; Luria, A.; Yang, J.; Murphy, S.; Friedman, D.; Hammock, B.; Vaughan, D.
Expression and regulation of soluble epoxide hydrolase in adipose tissue
Obesity (Silver Spring)
18
489-498
2010
Mus musculus
Qamar, W.; Khan, R.; Khan, A.Q.; Rehman, M.U.; Lateef, A.; Tahir, M.; Ali, F.; Sultana, S.
Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase
Toxicology
291
25-31
2011
Rattus norvegicus
Sun, D.; Cuevas, A.J.; Gotlinger, K.; Hwang, S.H.; Hammock, B.D.; Schwartzman, M.L.; Huang, A.
Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure
Am. J. Physiol. Heart Circ. Physiol.
306
H1146-H1153
2014
Mus musculus
Wang, Q.; Pang, W.; Cui, Z.; Shi, J.; Liu, Y.; Liu, B.; Zhou, Y.; Guan, Y.; Hammock, B.D.; Wang, Y.; Zhu, Y.
Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage
Am. J. Physiol. Renal Physiol.
304
F168-F176
2013
Homo sapiens
Gupta, N.C.; Davis, C.M.; Nelson, J.W.; Young, J.M.; Alkayed, N.J.
Soluble epoxide hydrolase: sex differences and role in endothelial cell survival
Arterioscler. Thromb. Vasc. Biol.
32
1936-1942
2012
Mus musculus
Lonsdale, R.; Hoyle, S.; Grey, D.T.; Ridder, L.; Mulholland, A.J.
Determinants of reactivity and selectivity in soluble epoxide hydrolase from quantum mechanics/molecular mechanics modeling
Biochemistry
51
1774-1786
2012
Mus musculus (P34914)
Purba, E.R.; Oguro, A.; Imaoka, S.
Isolation and characterization of Xenopus soluble epoxide hydrolase
Biochim. Biophys. Acta
1841
954-962
2014
Xenopus laevis
Thalji, R.K.; McAtee, J.J.; Belyanskaya, S.; Brandt, M.; Brown, G.D.; Costell, M.H.; Ding, Y.; Dodson, J.W.; Eisennagel, S.H.; Fries, R.E.; Gross, J.W.; Harpel, M.R.; Holt, D.A.; Israel, D.I.; Jolivette, L.J.; Krosky, D.; Li, H.; Lu, Q.; Mandichak, T.; Roethke, T.; Schnackenberg, C.G.; Schwartz, B.; Shewchuk, L.M.
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase
Bioorg. Med. Chem. Lett.
23
3584-3588
2013
Rattus norvegicus
Pecic, S.; Pakhomova, S.; Newcomer, M.E.; Morisseau, C.; Hammock, B.D.; Zhu, Z.; Rinderspacher, A.; Deng, S.X.
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors
Bioorg. Med. Chem. Lett.
23
417-421
2013
Homo sapiens
Burmistrov, V.; Morisseau, C.; Lee, K.S.; Shihadih, D.S.; Harris, T.R.; Butov, G.M.; Hammock, B.D.
Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors
Bioorg. Med. Chem. Lett.
24
2193-2197
2014
Homo sapiens
Shihadih, D.S.; Harris, T.R.; Yang, J.; Merzlikin, O.; Lee, K.S.; Hammock, B.D.; Morisseau, C.
Identification of potent inhibitors of the chicken soluble epoxide hydrolase
Bioorg. Med. Chem. Lett.
25
276-279
2015
Gallus gallus
Kim, I.H.; Lee, I.H.; Nishiwaki, H.; Hammock, B.D.; Nishi, K.
Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase
Bioorg. Med. Chem.
22
1163-1175
2014
Homo sapiens (P34913), Homo sapiens
Amano, Y.; Yamaguchi, T.; Tanabe, E.
Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography
Bioorg. Med. Chem.
22
2427-2434
2014
Homo sapiens (P34913)
Hung, Y.W.; Hung, S.W.; Wu, Y.C.; Wong, L.K.; Lai, M.T.; Shih, Y.H.; Lee, T.S.; Lin, Y.Y.
Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy
Brain Behav. Immun.
43
118-129
2015
Mus musculus
Harris, T.R.; Hammock, B.D.
Soluble epoxide hydrolase: gene structure, expression and deletion
Gene
526
61-74
2013
Homo sapiens (P34913), Homo sapiens
Nelson, J.W.; Subrahmanyan, R.M.; Summers, S.A.; Xiao, X.; Alkayed, N.J.
Soluble epoxide hydrolase dimerization is required for hydrolase activity
J. Biol. Chem.
288
7697-7703
2013
Homo sapiens (P34913), Homo sapiens
Chen, H.; Zhang, Y.; Ye, C.; Feng, T.T.; Han, J.G.
Insight into the binding modes and inhibition mechanisms of adamantyl-based 1,3-disubstituted urea inhibitors in the active site of the human soluble epoxide hydrolase
J. Biomol. Struct. Dyn.
32
1231-1247
2014
Homo sapiens
Woo, M.; Kim, H.; Lee, E.
Development and characterization of recombinant whole cells expressing the soluble epoxide hydrolase of Danio rerio and its variant for enantioselective resolution of racemic styrene oxides
J. Indust. Eng. Chem.
18
384-391
2012
Danio rerio (Q5PRC6)
-
Morisseau, C.; Wecksler, A.T.; Deng, C.; Dong, H.; Yang, J.; Lee, K.S.; Kodani, S.D.; Hammock, B.D.
Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation
J. Lipid Res.
55
1131-1138
2014
Homo sapiens (P34913), Homo sapiens
la Buscato, E.; Bloecher, R.; Lamers, C.; Klingler, F.M.; Hahn, S.; Steinhilber, D.; Schubert-Zsilavecz, M.; Proschak, E.
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors
J. Med. Chem.
55
10771-10775
2012
Homo sapiens
Lee, K.S.; Liu, J.Y.; Wagner, K.M.; Pakhomova, S.; Dong, H.; Morisseau, C.; Fu, S.H.; Yang, J.; Wang, P.; Ulu, A.; Mate, C.A.; Nguyen, L.V.; Hwang, S.H.; Edin, M.L.; Mara, A.A.; Wulff, H.; Newcomer, M.E.; Zeldin, D.C.; Hammock, B.D.
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy
J. Med. Chem.
57
7016-7030
2014
Rattus norvegicus, Homo sapiens (P34913), Homo sapiens
Lee, J.P.; Yang, S.H.; Lee, H.Y.; Kim, B.; Cho, J.Y.; Paik, J.H.; Oh, Y.J.; Kim, D.K.; Lim, C.S.; Kim, Y.S.
Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney
PLoS ONE
7
e37075
2012
Mus musculus
Zhang, W.; Davis, C.M.; Edin, M.L.; Lee, C.R.; Zeldin, D.C.; Alkayed, N.J.
Role of endothelial soluble epoxide hydrolase in cerebrovascular function and ischemic injury
PLoS ONE
8
e61244
2013
Homo sapiens
Froemel, T.; Jungblut, B.; Hu, J.; Trouvain, C.; Barbosa-Sicard, E.; Popp, R.; Liebner, S.; Dimmeler, S.; Hammock, B.D.; Fleming, I.
Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols
Proc. Natl. Acad. Sci. USA
109
9995-10000
2012
Danio rerio
de Oliveira, G.; Adriani, P.; Borges, F.; Lopes, A.; Campana, P.; Chambergo, F.
Epoxide hydrolase of Trichoderma reesei Biochemical properties and conformational characterization
Int. J. Biol. Macromol.
89
569-574
2016
Trichoderma reesei (G0R7E2), Trichoderma reesei, Trichoderma reesei QM9414 (G0R7E2)
Lee, K.S.; Henriksen, N.M.; Ng, C.J.; Yang, J.; Jia, W.; Morisseau, C.; Andaya, A.; Gilson, M.K.; Hammock, B.D.
Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase
Arch. Biochem. Biophys.
613
1-11
2017
Homo sapiens (P34913)
Liu, J.Y.; Tsai, H.J.; Morisseau, C.; Lango, J.; Hwang, S.H.; Watanabe, T.; Kim, I.H.; Hammock, B.D.
In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors
Biochem. Pharmacol.
98
718-731
2015
Homo sapiens (P34913), Homo sapiens, Mus musculus (P34914), Rattus norvegicus (P80299), Mus musculus C57BL/6 (P34914), Rattus norvegicus Sprague Dawley (P80299)
Burmistrov, V.; Morisseau, C.; Harris, T.R.; Butov, G.; Hammock, B.D.
Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability
Bioorg. Chem.
76
510-527
2018
Homo sapiens (P34913), Homo sapiens, Mus musculus (P34914), Mus musculus, Rattus norvegicus (P80299)
Amano, Y.; Tanabe, E.; Yamaguchi, T.
Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening
Bioorg. Med. Chem.
23
2310-2317
2015
Homo sapiens (P34913)
Takai, K.; Chiyo, N.; Nakajima, T.; Nariai, T.; Ishikawa, C.; Nakatani, S.; Ikeno, A.; Yamamoto, S.; Sone, T.
Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors
Bioorg. Med. Chem. Lett.
25
1705-1708
2015
Homo sapiens (P34913), Homo sapiens, Rattus norvegicus (P80299)
Hung, Y.; Hung, S.; Wu, Y.; Wong, L.; Lai, M.; Shih, Y.; Lee, T.; Lin, Y.
Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy
Brain Behav. Immun.
43
118-129
2015
Mus musculus (P34914), Mus musculus, Mus musculus C57BL/6 (P34914)
Gurung, A.B.; Mayengbam, B.; Bhattacharjee, A.
Discovery of novel drug candidates for inhibition of soluble epoxide hydrolase of arachidonic acid cascade pathway implicated in atherosclerosis
Comput. Biol. Chem.
74
1-11
2018
Homo sapiens (P34913)
Manickam, M.; Pillaiyar, T.; Boggu, P.; Venkateswararao, E.; Jalani, H.B.; Kim, N.D.; Lee, S.K.; Jeon, J.S.; Kim, S.K.; Jung, S.H.
Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase
Eur. J. Med. Chem.
117
113-124
2016
Oryctolagus cuniculus
Kim, J.H.; Cho, I.S.; Ryu, J.; Lee, J.S.; Kang, J.S.; Kang, S.Y.; Kim, Y.H.
In vitro and in silico investigation of anthocyanin derivatives as soluble epoxide hydrolase inhibitors
Int. J. Biol. Macromol.
112
961-967
2018
Homo sapiens (P34913)
Liu, Z.B.; Sun, C.P.; Xu, J.X.; Morisseau, C.; Hammock, B.D.; Qiu, F.
Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition kinetics and interaction mechanism merged with simulations
Int. J. Biol. Macromol.
133
1187-1193
2019
Homo sapiens (P34913)
Woo, M.H.;Kim, H.S.; Lee, E.Y.
Development and characterization of recombinant whole cells expressing the soluble epoxide hydrolase of Danio rerio and its variant for enantioselective resolution of racemic styrene oxides
J. Ind. Eng. Chem.
18
384-391
2012
Danio rerio (Q7ZVB4)
-
Yamanashi, H.; Boeglin, W.E.; Morisseau, C.; Davis, R.W.; Sulikowski, G.A.; Hammock, B.D.; Brash, A.R.
Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function
J. Lipid Res.
59
684-695
2018
Homo sapiens (P34913), Homo sapiens (Q9H6B9), Homo sapiens, Mus musculus (Q3V1F8), Mus musculus
Bloecher, R.; Lamers, C.; Wittmann, S.K.; Merk, D.; Hartmann, M.; Weizel, L.; Diehl, O.; Brueggerhoff, A.; Boss, M.; Kaiser, A.; Schader, T.; Goebel, T.; Grundmann, M.; Angioni, C.; Heering, J.; Geisslinger, G.; Wurglics, M.; Kostenis, E.; Bruene, B.; Steinhilber, D.; Schubert-Zsilavecz, M.; Kahn, K.a.h.n.t.
N-Benzylbenzamides a novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators
J. Med. Chem.
59
61-81
2016
Homo sapiens (P34913), Homo sapiens
Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Bloecher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fuerst, R.; Proschak, E.
Design, synthesis and cellular characterization of a dual inhibitor of 5-lipoxygenase and soluble epoxide hydrolase
Molecules
22
45-54
2016
Homo sapiens (P34913)
Mangels, N.; Awwad, K.; Wettenmann, A.; Dos Santos, L.R.; Froemel, T.; Fleming, I.
The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity
Prostaglandins Other Lipid Mediat.
125
30-39
2016
Mus musculus (P34914), Mus musculus C57BL/6 (P34914)
Abis, G.; Charles, R.L.; Eaton, P.; Conte, M.R.
Expression, purification, and characterisation of human soluble epoxide hydrolase (hsEH) and of its functional C-terminal domain
Protein Expr. Purif.
153
105-113
2019
Homo sapiens (P34913), Homo sapiens
Butov, G.; Burmistrov, V.; Danilov, D.
Synthesis and properties of 1-(R-adamant-1-yl)-3-(1-propionylpiperidin-4-yl)ureas and 4-({4-[3-(R-adamant-1-yl)ureido]cyclohexyl}oxy)benzoic acids, efficient target-oriented human soluble epoxide hydrolase inhibitors
Russ. Chem. Bull.
66
1876-1880
2017
Homo sapiens (P34913)
-
Burmistrov, V.; Butov, G.; Karlov, D.; Palyulin, V.; Zefirov, N.; Morisseau, C.; Hammock, B.
Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase
Russ. J. Bioorg. Chem.
42
404-414
2016
Homo sapiens (P34913)
-
Butov, G.; Burmistrov, V.; D'yachenko, V.
Synthesis and properties of symmetrical N,N-bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors
Russ. J. Org. Chem.
53
977-980
2017
Homo sapiens (P34913)
-
Hiesinger, K.; Kramer, J.S.; Beyer, S.; Eckes, T.; Brunst, S.; Flauaus, C.; Wittmann, S.K.; Weizel, L.; Kaiser, A.; Kretschmer, S.B.M.; George, S.; Angioni, C.; Heering, J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Schmidtko, A.; Pogoryelov, D.; Pfeilschifter, J.; Hofmann, B.; Steinhilber, D.; Sch, S.c.h.w.
Design, synthesis, and structure-activity relationship studies of dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase
J. Med. Chem.
63
11498-11521
2020
Homo sapiens
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