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Literature summary for 3.3.2.10 extracted from

  • Hwang, S.H.; Wagner, K.M.; Morisseau, C.; Liu, J.Y.; Dong, H.; Wecksler, A.T.; Hammock, B.D.
    Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase (2011), J. Med. Chem., 54, 3037-3050.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
4-(5-phenyl-3-[3-[3-(3-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase Homo sapiens
4-(5-phenyl-3-[3-[3-(4-trifluoromethoxy-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase Homo sapiens
4-(5-phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase Homo sapiens
4-(5-phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase. Inhibitor shows the best pharmacokinetic profiles in both mice and rats. Following subcutaneous administration at 10 mg/kg, compound exhibits antiallodynic activity that is more effective than the same dose of either COX-2 inhibitor celecoxib or sEH inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid alone, as well as coadministration of both inhibitors Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-
Mus musculus
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000005
-
 pH 7.0, 30°C Homo sapiens 4-(5-phenyl-3-[3-[3-(4-trifluoromethoxy-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
0.0000009
-
 pH 7.0, 30°C Homo sapiens 4-(5-phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
0.0000041
-
 pH 7.0, 30°C Homo sapiens 4-(5-phenyl-3-[3-[3-(3-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide