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Literature summary for 3.3.2.10 extracted from

  • Jones, P.D.; Tsai, H.J.; Do, Z.N.; Morisseau, C.; Hammock, B.D.
    Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase (2006), Bioorg. Med. Chem. Lett., 16, 5212-5216.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
modeling of structure in complex with inhibitor N-(1-trifluoroacetylpiperidin-4-yl)-N'-(adamant-1-yl) urea Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methyl 2-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
-
 Homo sapiens
methyl 2-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
-
 Homo sapiens
methyl 3-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
-
 Homo sapiens
methyl 3-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
-
 Homo sapiens
methyl 4-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
-
 Homo sapiens
methyl 4-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
-
 Homo sapiens
methyl 5-oxo-5-(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)pentanoate
-
 Homo sapiens
methyl 5-oxo-5-[4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]pentanoate
-
 Homo sapiens
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea
-
 Homo sapiens
N-(1-trifluoroacetylpiperidin-4-yl)-N'-(adamant-1-yl) urea
-
 Homo sapiens
N-([1-(phenylcarbonyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
-
 Homo sapiens
N-([1-(trifluoroacetyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
-
 Homo sapiens
N-[1-(phenylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
-
 Homo sapiens
N-[1-(pyridin-2-ylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000011
-
-
 Homo sapiens methyl 3-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
0.0000011
-
-
 Homo sapiens methyl 4-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
0.0000011
-
-
 Homo sapiens N-(1-trifluoroacetylpiperidin-4-yl)-N'-(adamant-1-yl) urea
0.0000012
-
-
 Homo sapiens N-([1-(phenylcarbonyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
0.0000013
-
-
 Homo sapiens N-[1-(phenylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
0.0000015
-
-
 Homo sapiens methyl 4-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
0.0000017
-
-
 Homo sapiens methyl 2-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
0.0000018
-
-
 Homo sapiens methyl 2-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
0.0000018
-
-
 Homo sapiens N-[1-(pyridin-2-ylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
0.0000027
-
-
 Homo sapiens methyl 5-oxo-5-[4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]pentanoate
0.0000032
-
-
 Homo sapiens N-([1-(trifluoroacetyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
0.0000034
-
-
 Homo sapiens methyl 5-oxo-5-(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)pentanoate
0.0000041
-
-
 Homo sapiens methyl 3-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
0.000007
-
-
 Homo sapiens N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea