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Literature summary for 3.3.2.10 extracted from

  • Marino, J.P.
    Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery (2009), Curr. Top. Med. Chem., 9, 452-463.
    View publication on PubMed
Search for more literature for 3.3.2.10

Application

Application Comment Organism
drug development sEH is a cross-functional target with the potential for therapeutic utility in the areas of hypertension, inflammation, and organ protection Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
 Mus musculus
1-(3-[[3-(morpholin-4-yl)propyl]sulfonyl]phenyl)-3-[4-(trifluoromethyl)phenyl]urea
-
 Mus musculus
1-(4-chlorophenyl)-3-[4-[4-(morpholin-4-yl)benzoyl]cyclohex-2-yn-1-yl]urea
-
 Mus musculus
1-(4-[[4-(2-methoxyethyl)piperazin-1-yl]carbonyl]phenyl)-3-[4-(trifluoromethyl)phenyl]urea
-
 Mus musculus
1-(cis-4-methoxycyclohexyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
-
 Mus musculus
1-[1-(methylsulfonyl)piperidin-4-yl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[3-(morpholin-4-ylcarbonyl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
-
 Mus musculus
1-[4-[2-(2-ethoxyethoxy)ethoxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[4-[2-(2-ethoxyethoxy)ethoxy]phenyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[4-[2-(morpholin-4-yl)ethoxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[5-[3-(morpholin-4-yl)propoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[cis-4-(4-fluorophenoxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[cis-4-(4-methoxyphenoxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[cis-4-(benzyloxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[cis-4-(cyclohexylmethoxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[cis-4-[(2-methylbenzyl)oxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
1-[cis-4-[(4-bromobenzyl)oxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Mus musculus
12-(3-adamantan-1-yl-ureido)-dodecanoic acid i.e. AUDA, binding structure, overview Mus musculus
2,4-dichloro-N-[4-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]benzamide
-
 Mus musculus
2-(benzylamino)-N-[4-[3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]pyridine-3-carboxamide
-
 Mus musculus
4'-(methylsulfonyl)-N-[4-[3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]biphenyl-3-carboxamide
-
 Mus musculus
4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
 Mus musculus
4-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
 Mus musculus
4-[[([4-[(4-[(2-phenylethyl)amino]-6-[[(2R)-2-phenylpropyl]amino]-1,3,5-triazin-2-yl)amino]cyclohexyl]carbonyl)amino]methyl]benzoic acid
-
 Mus musculus
4-[[4-(azepan-1-yl)-6-(methylamino)-1,3,5-triazin-2-yl]amino]-N-[2-(trifluoromethoxy)benzyl]cyclohexanecarboxamide
-
 Mus musculus
4-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)cyclohexyl]sulfonyl]benzoic acid
-
 Mus musculus
6-cyano-N-[3-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl]-1,6-dihydropyridine-3-carboxamide
-
 Mus musculus
7-butyl-N-(2,3-dimethoxybenzyl)-6-(3,4,5-trimethoxyphenyl)-7H-cyclopenta[b]pyridine-3-carboxamide
-
 Mus musculus
additional information design and synthesis of small molecule enzyme inhibitors Mus musculus
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
 Mus musculus
N-(2,4-dichlorobenzyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide
-
 Mus musculus
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Mus musculus
N-(4-chlorophenyl)-5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxamide
-
 Mus musculus
N-(4-chlorophenyl)piperidine-1-carboxamide
-
 Mus musculus
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
 Mus musculus
N-cyclohexyl-N'-decylurea i.e. CDU, binding structure, overview Mus musculus
N-[(3-chloro-4'-fluorobiphenyl-4-yl)methyl]-6-[3-(trifluoromethoxy)phenoxy]pyridine-3-carboxamide
-
 Mus musculus
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-4-(tricyclo[3.3.1.13,7]dec-1-yl)butanamide
-
 Mus musculus
N-[4-(butan-2-yl)phenyl]-3H-indole-3-carboxamide
-
 Mus musculus
N-[4-(butan-2-yl)phenyl]-5-methyl-1,2-oxazole-4-carboxamide
-
 Mus musculus
N-[4-bromo-2-(trifluoromethoxy)benzyl]-6-(4-fluorophenyl)pyridine-3-carboxamide
-
 Mus musculus
N-[4-[(4-chlorophenyl)sulfonyl]cyclohexyl]-2-hydroxy-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
 Mus musculus
N-[4-[3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzyl]pyridine-3-carboxamide
-
 Mus musculus
N-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-b-alanine
-
 Mus musculus
N1-(2,4-dichlorobenzyl)-N4-(2-methoxyethyl)piperidine-1,4-dicarboxamide
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000
-
 2 * 62000 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P34914
-
-

Reaction

Reaction Comment Organism Reaction ID
an epoxide + H2O = a glycol catalytic reaction mechanism involving Tyr465, Tyr381, Asp495, His523, and Asp333, overview Mus musculus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 62000 Mus musculus

Synonyms

Synonyms Comment Organism
More the enzyme belongs to a family of enzymes which catalyze the hydrolysis of epoxyeicosatrienoic acids Mus musculus
SEH
-
 Mus musculus